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Yıl:2023; Cilt: 60; Sayı: 4>> Özet
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Nöropsikiyatri Arşivi; 2023;60(4):298-303
Amyotrofik Lateral Sklerozda Devam Eden Denervasyon ve Reinnervasyonun Tek Lif Elektromiyografi Yöntemi ile Konsantrik İğne Elektrodu Kullanılarak İncelenmesi
P Bekdik , MB Baslo
İstanbul Üniversitesi, İstanbul
Amaç: Bu çalışmanın amacı, amyotrofik lateral skleroz (ALS) hastalığının tanısında konsantrik iğne (Kİ) elektrot ile jitter ölçümü yapılarak nöromusküler bileşke iletim aksamasını ekstremite dışı bir kasta göstermek ve süregelen reinnervasyon belirteci olarak pik sayısı ile değerlendirmenin kullanılabilirliğini araştırmaktır. Yöntem: Bu çalışmaya ALS tanısı konan 12 gönüllü hasta dâhil edildi. Sağ ekstansör dijitorum komünis (EDC) ve sol frontalis kaslarının istemli kasısı sırasında bir Kİ elektrodu kullanılarak tek lif elektromiyografi (TLEMG) yapıldı. Bulgular: Sağ ekstansör dijitorum komünis kasından yapılan TLEMG’de hepsinde ortalama jitter değeri yüksekti. Ekstansör dijitorum komünis kaslarında hesaplanan ortalama jitter 57,76±24,17 µs µs’dir. Frontal kaslarda ortalama jitter değeri 28,91±10,21 µs. µs idi. Tüm hastalarda Kİ elektrot “pik sayısı” EDC kasında 4’ün üzerinde ve frontal kasın %91,67’sinde 4’ün üzerindeydi. Sonuç: Tek lif elektromiyografi incelemesinde yüksek jitter saptanması, pik sayısı değerlerinin artması durumunda incelenen kasın denervasyonreinnervasyon sürecine girdiğini gösterir. Ekstremite kaslarında böyle bir tespit yapıldığında ALS tanısı için önem kazanmaktadır
Investigation of Ongoing Denervation and Reinnervation in Amyotrophic Lateral Sclerosis byUsing Concentric Needle Electrode with Single Fiber Electromyography Method
Introduction: The aim of this study is to demonstrate the conduction disturbance at the neuromuscular junction in a cranial muscle by measuring jitter with a concentric needle (CN) electrode in the diagnosis of Amyotrophic Lateral Sclerosis (ALS) and to investigate the utility of evaluating the peak number as an ongoing reinnervation marker. Method: Twelve patients diagnosed with ALS were included in this study. Single fiber electromyography (SFEMG) was performed using a CN electrode during the voluntary contraction of the right extensor digitorum communis (EDC) and left frontalis muscles. Results: In SFEMG from the right EDC muscle, the mean jitter value was high in all of them. The average jitter calculated in EDC muscles was 57.76±24.17 µs. The mean jitter value in the frontal muscles was 28.91±10.21 µs. In all patients, the number of CN electrode peaks was more than 4 in the EDC muscle and above 4 in 91.67% of the frontal muscle. Conclusion: Detection of high jitter in SFEMG examination indicates that the examined muscle undergoes a denervation-reinnervation process in the case of increased peak number values. When such a determination is made in the extremity muscles, it becomes important for the diagnosis of ALS

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