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Yıl:2024; Cilt: 35; Sayı: 3>> Özet
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Türk Psikiyatri Dergisi; 2024;35(3):214-224
Yaşlanmanın Yüz ve İsim Tanıma Üzerindeki Etkisi: Bir fMRG Çalışması
Ö Uslu, S Eroğlu, K Oğuz, D İşman, MC Erata, Y Erdoğan, Ö Kan, AS Gönül
Ege Üniversitesi, İzmir
Amaç: Bu çalışmanın amacı ilerleyen yaşla birlikte bellek görevi sırasında beyindeki fonksiyonel değişiklikleri tespit etmek ve bu değişikliklerin bellek performansıyla ilişkisini incelemektir. Yöntem: Çalışmaya Genç Yetişkin Grup (GYG; N=20; 20-25 yaş) ve İleri Yaş Grup (İYG; N=18; 60-70 yaş) olmak üzere iki grup dahil edilmiştir. Gruplara Montreal Bilişsel Değerlendirme (MoCA) puanları 21’in üstünde olan ve birinci dereceden akrabalarında Alzheimer Hastalığı öyküsü olmayan kişiler dahil edilmiştir. Katılımcılara yüz ve isimlerin öğrenildiği kodlama, yüz tanıma ve isim tanıma alt görevlerini içeren bellek görevi sırasında Fonksiyonel Manyetik Rezonans Görüntüleme (fMRG) çekimi yapılmıştır. Bulgular: GYG’a göre, İYG’de yüz tanıma görevinde sol posterior singulat korteks, sol süperior frontal korteks, sol fusiform yüz tanıma alanında; isim tanıma görevinde sol süperior frontal korteks, sağ prefrontal korteks, sol anterior+posterior singulat kortekste aktivite artışı bulunmuştur. İYG yüz tanıma ve isim tanıma bellek testlerinde daha düşük doğru sayısına sahiptir (sırasıyla p=0,026; p=0,001). Sonuç: Bulgular İYG’de bellek görevi sırasında beyinde daha yaygın bir aktivasyon ortaya çıktığını tespit etmiştir. Bu durum ilerleyen yaşla birlikte bellekteki bilgiler hatırlanırken kişilerin daha fazla nöral ve bilişsel kaynağa ihtiyaç duyduğunu göstermektedir.
The Effect of Aging on Face-Name Recognition: An fMRI Study
Objective: The aim of this study is to detect functional changes in the brain during the memory task with aging and the association between functional changes and memory performance. Method: The study consisted of Young Adult Group (YAG, n=20) aged 20 to 25 and Late Adult Group (LAG, n=18) aged 60 to 70. Individuals with Montreal Cognitive Assessment (MoCA) scores above 21 and no family history of Alzheimer’s Disease were included in the study. Functional Magnetic Resonance Imaging (fMRI) scanning was performed on all participants during a memory task including encoding (face and name), face and name recognition sub-tasks. Results: Results indicated that LAG showed increased activity during face recognition task in left posterior cingulate cortex, left superior frontal cortex, left fusiform face area and another increased activity was found out during name recognition task in left superior frontal cortex, right prefrontal cortex, left anterior + posterior cingulate cortex. The accuracy of face recognition and name recognition memory tests were significantly lower in LAG (respectively, p=0.026; p=0.001). Conclusion: These results indicated that advanced age were associated with more widespread activation in brain during memory task. Thus with aging, individuals require more neuronal and cognitive resources during memory processing.

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