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Yıl:2024; Cilt: 61; Sayı: 1>> Özet
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Nöropsikiyatri Arşivi; 2024;61(1):55-58
HbA1c Yüksekliği Olan Hastalarda Subklinik Polinöropati Varlığı
Y Çetinkaya, G Özdemir, B R Hasırcı Bayır, C H Mısırlı
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, İstanbul
Amaç: Asemptomatik HbA1c yüksekliği ile polinöropati oluşumu arasındaki ilişkinin normoglisemik durumla karşılaştırılarak araştırılması amaçlanmıştır. Yöntem: Çalışmaya, hastanemiz kliniklerine Ocak-Mart 2017 tarihleri arasında nöropati dışındaki semptomlarla başvuran ve subklinik HbA1c yüksekliği saptanan 30 kadın hasta ile normoglisemik sağlıklı 30 kadın hasta dâhil edilmiş ve bu hastalarda sinir ileti incelemesi yapılmış, iki grubun parametreleri birbiriyle karşılaştırılmıştır. Bulgular: Amplitüd dağılımı açısından; kontrol grubu ile karşılaştırıldığında, tibial motor ve ulnar duysal sinir amplitüdü, kontrol grubundan düşüktür (p<0,05). Peroneal, median ve ulnar motor sinirlerde distal latans değerleri kontrol grubuna göre uzamıştır (p<0,05). Sural, median ve ulnar duysal sinir latansları kontrol grubuna göre uzamıştır. İleti hızı dağılımı açısından; sural, median ve ulnar duysal sinirde ileti hızı kontrol grubuna göre yavaşlamıştır (p<0,05) Sonuç: Subklinik HbA1c yüksekliği olan asemptomatik olgularda periferik sinir tutulumu izlenmiş olup, hastalarda nöropati gelişimini engellemek için erken dönemde glisemik kontrol sağlanmalıdır.
Presence of Subclinical Polyneuropathy in Patients with Elevation of Hba1c
Introduction: It is aimed to investigate the relationship between the asymptomatic elevation of HbA1c and occurrence of polyneuropathy by way of comparison to normoglycemic condition. Methods: The study includes 30 female patients diagnosed with subclinical elevation of HbA1c and 30 normoglycemic healthy female patients who applied to our hospital polyclinics with symptoms other than neuropathy between January-March 2017. Nerve conduction examination is done in these patients, parameters of both groups are compared. Results: In regard to amplitude distribution; when compared to control group, tibial motor and ulnar sensory nerve amplitude is lower than the control group (p<0.05). In peroneal, median and ulnar motor nerves, distal latency values are extended compared to control group (p<0.05). Sural, median and ulnar sensory nerve latency is extended compared to control group. In terms of transmission rate distribution; in sural, median and ulnar sensory nerve, transmission speed is lower compared to the control group (p<0.05) Conclusions: In asymptomatic cases with subclinical elevation of HbA1c, peripheral nervous system involvement is monitored, and early glycemic control should be provided in order to prevent development of neuropathy in patients.

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