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Yıl:2021; Cilt: 32; Sayı: 1>> Özet
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Türk Psikiyatri Dergisi; 2021;32(1):61-64
Paroksetin Kullanımına Bağlı Saç Dökülmesi: Bir Olgu Sunumu
F Kurhan, GZ Kamış
Yüzüncü Yıl Üniversitesi, Van
Psikotrop ilaçların kullanımı ile bildirilen yan etkilerin içinde çeşitli dermatolojik yan etkiler mevcuttur. Aşırı duyarlılık reaksiyonları, Stevens-Johnson sendromu gibi ciddi yan etkiler yanında ekimoz, saç dökülmesi gibi daha hafif yan etkiler de görülebilir. Saç dökülmesi sıklıkla duygudurum dengeleyicilerle ilişkili olarak gözlenirken nadiren de antidepresanlarla ilişkili olabileceği bildirilmektedir. Depresyon, anksiyete bozuklukları, obsesif kompulsif bozukluk spektrumu tedavisinde birinci basamakta tercih edilmekte olan seçici serotonin geri alım inhibitörleri en sık kullanılan antidepresan ilaçlardır. Birçok dermatolojik hastalığa eşlik eden psikiyatrik bozukluklar olduğu bilinmektedir. Psikiyatrik eş tanılara yönelik tedavi verilmesinin dermatolojik hastalıkların gidişi, sonlanışı, hastalığa uyum süreci üzerine olumlu etkileri mevcuttur. Bu açılardan düşük yan etki profili nedeni ile özellikle seçici serotonin geri alım inhibitörleri (SSGİ) tedavide kullanılmaktadır. Biz burada paroksetin kullanan sosyal anksiyete bozukluğu tanılı 24 yaşındaki erkek hastada paroksetin kullanımı sırasında gelişen saç dökülmesi olgusunu sunmaktayız. Bu olguda görülen saç dökülmesinin paroksetin tedavisinin kesilmesi sonrası düzeldiği, tekrar paroksetin kullanımı ile tekrarladığı, paroksetin yine kesilince düzeldiği ve başka bir SSGİ olan sertralin ile yinelemediği gözlenmiştir.
Hair Loss Associated with Paroxetine Use: A Case Report
Diverse dermatological side effects in relation to using psychotropic agents, include the serious outcomes as hypersensitivity and StevensJohnson syndrome as well as milder forms as ecchymosis and hair loss. Whereas hair loss is frequently associated with mood stabilizers, rarely ,it is also attributed to antidepressants. Selective serotonin reuptake inhibitors (SSRIs) which are the first choice treatment for depression, anxiety disorders and obsessive-compulsive spectrum disorders, are the most commonly used antidepressant drugs. Psychiatric comorbidities have been known in many dermatological diseases and their treatment have positive effects on the course and outcome as well as on the adaptation process to the disease. Due to their favorable side effect profile, for comorbid cases SSRIs are frequently used. Here we present a case of hair loss during paroxetine in a 24-year-old male with social anxiety disorder. In this case the hair loss improved after discontinuing and recurred after resuming paroxetine. After replacing paroxetine with sertraline, another SSRI, alopecia did not recur.

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