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Yıl:2020; Cilt: 7; Sayı: 2>> Özet
TAM METİN
The Journal of Neurobehavioral Sciences; 2020;7(2):85-90
Panik Bozukluǧu Hastalarinda Ve Birinci Derece Yakinlarinda Anksiyete Duyarliliǧi Ve Panik Agorafobi Spektrumu Belirtileri
H Bulut, B Ulug
 SBÜ Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi, İstanbul
Bu araştırmada panik bozukluǧu tanısı konan hastalarda ve birinci derece yakınlarında anksiyete duyarlılıǧı ölçümlerinin ve panik-agorafobi spektrumu belirtilerinin incelenmesi ve karşılaştırılması amaçlanmıştır. Bir üniversite tıp fakültesi hastanesi psikiyatri polikliniǧinde panik bozukluǧu tanısı konulan veya bu tanı ile izlenmekte olan 80 hasta ile bu hastaların birinci derece yakınları (80 hasta kardeşi) klinik deǧerlendirme sonrası çalışma kapsamına alınmışlardır. Hastalara sosyo-demografik bilgi formu, DSM-IV Eksen I Bozuklukları İçin Yapılandırılmış Klinik Görüşme (SCID-1), Anksiyete Duyarlılık Ölçeǧi (ADÖ), Durumluk-Sürekli Kaygı Ölçeǧi (DSKÖ), Beck Depresyon Ölçeǧi (BDÖ), Panik-Agorafobi Ölçeǧi (PAÖ) ve Yaşamboyu Panik-Agorafobi Spektrumu Ölçeǧi (PASÖ-YB); kardeşlerine ise sosyo-demografik bilgi formu, SCID-1, ADÖ, DSKÖ, BDÖ, PASÖ-YB uygulanmıştır. Yapılan deǧerlendirmeler sonucunda, hastaların ADÖ puanlarının, kardeşlerinin puanlarından, istatistiksel olarak anlamı şekilde yüksek olduǧu saptanmıştır (p < 0.01). Ayrıca hastalar PASÖ-YB ölçeǧinden kardeşlere göre anlamlı derecede yüksek puan almışlardır (p < 0.01). BDÖ puanı kovaryant olarak analize alındıǧında anksiyete duyarlılıǧı ve panik-agorafobi spektrumu belirtilerini gösterme açısından farklılık kaybolmamaktadır. Sonuç olarak panik bozukluǧunda, birinci derece hasta yakınlarında endofenotipik özellikler olarak araştırılmış olan iki deǧişken olan anksiyete duyarlılıǧı ve spektrum belirtilerinin şiddet ve sıklık bakımından hasta grubundan farklı olduǧu saptanmıştır.
Anxiety Sensitivity And Panic-Agoraphobic Spectrum Symptoms İn Patients With Panic Disorder And Their First Degree Relatives
The aim of the study was to investigate and compare anxiety sensitivity measurements and panic-agoraphobic spectrum symptoms in patients diagnosed with panic disorder and in their first degree relatives. Eighty patients who were on follow-up or recently diagnosed as panic disorder in a university faculty of medicine psychiatry department and their first degree relatives (80 siblings) were included after clinical evaluation. The patients were assessed with socio-demographic information form, Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-1), Anxiety Sensitivity Index (ASI), State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI), Panic-Agoraphobic Scale (PAS) and Lifetime Panic-Agoraphobic Spectrum Self Report (PAS-SR lifetime); and their siblings were assessed with socio-demographic information form, SCID-1, ASI, STAI, BDI, and PAS-SR lifetime. According to the results of the study, it was determined that the ASI scores of the patients were statistically significantly higher than the scores of their siblings (p < 0.01). In addition, patients scored significantly higher on the PAS-SR lifetime scale than siblings (p < 0.01). Inclusion of BDI scores in covariant analysis has made no change in the difference among study groups in level of anxiety sensitivity and degree of panic agoraphobic spectrum. As a conclusion, in this study, it was found that anxiety sensitivity and spectrum symptoms, which are two variables investigated as endophenotypic features in the first degree relatives in the panic disorder, differ from the patient group in terms of severity and frequency.

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