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Pedal edema due to drugs is common especially with beta blockers, calcium channel blockers, non-steroidal antiinflammatory drugs, and several hormonal drugs but they can rarely occur with new generation atypical antipsychotics. There are case reports with risperidone especially as peripheral edema. We present two male patients (Case A: 51-yearold, diagnosed with bipolar disorder type 2; Case B: 55-year-old, diagnosed with psychotic disorder plus mild mental retardation) who developed bilateral pedal edema after treatment with risperidone. Risperidone treatment in the elderly should be carefully decided because even small doses of risperidone may increase risk of edema.