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Yıl:2016; Cilt: 3; Sayı: 1>> Özet
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Türk Uyku Tıbbı Dergisi; 2016;3(1):6-9
Obstrüktif Uyku Apne Sendromlu Hastalarda Oksijen Desatürasyonu ve Beck Depresyon İndeksi İlişkisi
S Demir
Turgut Özal Üniversitesi, Ankara
Amaç: Obstrüktif uyku apne sendromlu (OUAS) hastalarda, hastalık ağırlığı ile orantılı olarak uyku fragmantasyonu gerçekleşir. Hastalarda, derin uyku azalır. Yetersiz uyku, bilişsel bozukluklar, karakter ve kişilik değişikliklerine bağlı depresyon görülme oranı artar. Bu çalışmada amacımız, OUAS’lı hastalarda oksijen desatürasyon miktarı artışı ile Beck depresyon indeksi (BDİ) arasında ilişkiyi incelemekti. Gereç ve Yöntem: Laboratuvarımıza başvuran ve polisomnografi (PSG) yapılan iki yüz on dokuz hasta için kayıtlardan, retrospektif ve kesitsel olarak yararlanılması hedeflendi. PSG ile OUAS tanısı alan 18-78 yaş aralığındaki hastalardan, hastalık ağırlığı hafif olan elli yedi, orta olan elli dört ve ağır olan elli iki hastanın, PSG’de Solunum bozukluğu indeksi <5 olan elli altı hastanın da kontrol grubu olarak alınması planlandı. Çalışmaya dahil edilen hastalarda, müraacatları esnasında rutin olarak değerlendirilen BDİ bakılması planlandı. Depresyon ve diğer majör psikiyatrik hastalık tanılı hastalar ve PSG kayıtları yapıldığı zaman depresyon tedavisi almakta olan hastalar çalışmaya dahil edilmedi. BDİ sonuçlarına göre; depresyon seviyesinin 0-13 arası normal, 14-19 arası hafif, 20-28 arası orta, 29 ve üstünü ağır olarak değerlendirilmesi planlandı. Bulgular: Tüm popülasyona bakıldığında BDİ normal veya hafif depresyonla uyumlu geldiği izlendi. Hastalık ağırlığı artışıyla beraber oksijen desatürasyonunun arttığı izlendi. OUAS’lı hastalarda kontrole göre BDİ ile oksijen desatürasyonu arasında ilişki saptanmadı. Sonuç: OUAS’ta, özellikle uyku fragmentasyonu ve kronik uykusuzluk nedeniyle depresyon sık görülmektedir. Ancak çalışmamızda, normal ya da hafif depresif bulguları olan hastaların olduğu görüldü. OUAS’lı hastalarda kontrole göre BDİ ile oksijen desatürasyonu arasında ilişki saptanmadı. Yani hipokseminin depresyonu tetiklemediği, tamamen yetersiz uyku ve uyku derinliğindeki azalmalara bağlı mod değişiklikleri olduğunu düşündürdü.
Oxygen Desaturation and Beck Depression Inventory Relationship in Patients with Obstructive Sleep Apnea Syndrome
Objective: Sleep fragmentation occurs proportionally with the severity of disease in Obstructive sleep apnea syndrome (OSAS) patients. Deep sleep decreases in patients. Depression incidence increases depending on poor sleep, cognitive impairment, and the character and personality changes. Our aim in this study, we examined the relationship between oxygen desaturation and the Beck depression index (BDI) in patients with OSAS. Materials and Methods: Two hundred nineteen patients with polysomnography (PSG) and BDI records were included in this crosssectional and retrospective study. The age range of patients was in 18-78. In OSAS group, 57 patients were mild [respiratory disturbance index (RDI): 5-15)]; 54 patients were moderate (RDI: 15.1-30); 52 patients were severe (RDI: >30). Fifty-six patients (RDI <5) were control group. Exclusion criterions were major depression, other psychiatric disorders and to receive depression treatment when PSG recordings were made. The results of Beck depression inventory were evaluated according to the criterion that BDI: 0-13 normal; BDI: 14-19 mild depression, BDI: 20-28 moderate depression, BDI: >29 severe depression. Results: The results of Beck Depression Index were observed as normal or mild depression at whole study population. The oxygen desaturation in patients with OSAS was increasing due to the severity of disease. But, between BDI and the oxygen desaturation there was no correlation in OSAS patients as compared with the control group. Conclusion: Depression is common due to chronic insomnia and especially fragmentation of sleep in OSAS. However, in our study, we observed the patients with normal or mild depressive symptoms. Between BDI and the oxygen desaturation there was no correlation. Hypoxemia was not provoked depression, however was suggested in the mood changes that due to insufficient sleep and the reduction of sleep depth.

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