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Yıl:2005; Cilt: 25; Sayı: >> Özet
TAM METİN
Psikoloji Çalışmaları; 2005;25():31-48
Aydınlık: Karanlık Döngüsünün Modülasyonunun Porsolt Yüzme Testindeki Antidepresan Etkilerinin Zamansal Sınırları
TA Karslı
İstanbul Üniversitesi, İstanbul
Bu çalışma kapsamındaki iki deneyde 24 saatlik aydınlık-karanlık döngüsünü aydınlık-aydınlık döngüsünü değiştirmenin anlidepresan etkinliği incelenmiştir. Aydınlık-karanlık döngüsünün karanlık fazında bir gecelik olarak verilen 12 saatlik ışık pulsünün dişi Wistar sıçanların 24 saat aralıkla uygulanan yüzme lestindeki (PST) performansı üzerine etkinliği ve bu etkinliğin zamansal sınırları araştırılmıştır. Bu deneyde 3 adet deney grubu, bu deney gruplarının herbirinin kendi kontrol grubu ve bir adet de herhangi bir manipulasyona maruz kalmamış olan temel kontrol grubu olmak üzere 7 gruba random olarak dağıtılmış olan 56 adet dişi Wistar sıçan kullanılmıştır. Deneysel manipulasyonun sona ermesinden, bağlı bulundukları gruba göre, 24, 96 ya da 168 saat sonra yüzme testine tabi tutulmuşlardır. İstatistik analizler ışığın koruyucu anlidepresan etkinliğinin ışık pulsünün sona ermesinden 168 saat sonra bile etkili olduğunu göstermiştir. *
Temporal limitations of the antidepressant-like effects of modulating light-dark cycle OH Porsolt Swimming Test
This study aimed to determine temporal extent of the antidepressant?like effect of modulating Light:Dark cycle in Light:Light direction for one session. Fifty-six female Wistar rats were randomly allocated either to one of 3 experimental or 4 control groups, which underwent to Porsolt Swimming Test sessions separated by 24 hours, after 24,96 or 168 hours following the offset of manipulation. Animals in the fourth control group, called as the no treatment group, were kept in vivarium and underwent only the PST trials without any manipulation. Antidepressant-like protective effects of light were observed to extend to ¡68 hours.

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