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Yıl:2014; Cilt: 1; Sayı: 1>> Özet
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Türk Uyku Tıbbı Dergisi; 2014;1(1):16-21
Obstrüktif Uyku Apnesinde Apne ve Hipopne İçeriğindeki Cinsiyet Farkı
M Yüceege, H Fırat, S Ardıç, AU Demir
Dışkapı Yıldırım Beyazıt Research and Educational Hospital, Ankara, Turkey
Giriş: Obstrüktif uyku apneli kadın ve erkeklerde demografik verilerle beraber apne ve hipopne yapısını ayrı olarak incelemeyi amaçladık. Gereç ve Yöntem: Dışkapı Yıldırım Beyazıt Araştırma ve Eğitim Hastanesi Uyku Merkezi’ne horlama, tanıklı apne ve/veya uykululuk ile Aralık 2010-Haziran 2012 tarihleri arasında başvuran ve polisomnografi (PSG) yapılan hastalar sırayla çalışmama alındı. PSG raporları retrospektif olarak değerlendirildi. Uyku etkinlikleri %40’ın altında olanlar çalışma dışı bırakıldı. Vücut kitle indeksi (VKİ), boyun çevresi (BÇ), karın çevresi (KÇ) ve PSG değerleri kaydedildi. Bulgular: Toplam 406 hasta (250 erkek, 156 kadın) çalışmaya alındı. BÇ erkeklerde, KÇ ve VKİ anlamlı olarak yüksek bulundu. Ortalama yaş, apne-hipopne indeksi (AHİ) ve %3 oksijen desaturasyon indeksi (ODİ) iki cinsiyette benzerdi. Erkeklerde total yüzeyel uyku (Evre 1+2) daha fazlayken Evre 3 (Yavaş Dalga Uykusu: YDU) kadınlarda daha fazlaydı. Erkeklerde total apne sayısı, kadınlarda hipopneler anlamlı derecede fazlaydı. AHİ’ini erkekte etkileyen faktörler BÇ ve VKİ iken kadınlarda KÇ ve VKİ idi. Sonuç: Benzer apne-hipopne indeksi olan bir grup hastada kadınların daha hipopneik, erkeklerin daha apneik olduğunu saptadık. Cinsiyetlerde yağ dağılımındaki farklılığın apne/hipopne ağırlığında etkili olması muhtemel gözükmektedir. Apne ve hipopne indekslerinin ayrı ayrı önemi YDU yüzdesi ile ilişkilendirilebilir. Apne ve hipopnelerin her iki cinsiyette morbidite ve mortalite üzerindeki etkilerini değerlendirmek için prospektif araştırmalara ihtiyaç vardır.
Gender Difference in Apnea and Hypopnea Componentin Obstructive Sleep Apnea
Introduction: We aimed to analyze the apnea and hypopnea structure separately with demographic parameters and sleep architecture in men and women with sleep apnea. Materials and Methods: Patients referred for snoring, witnessed apnea and/or day time sleepiness to Diskapi Yildirim Beyazit Research and Educational Hospital Sleep Center and gone under polysomnography (PSG) between December 2010 and June 2012 were taken in order. PSG reports were analyzed retrospectively. The patients with sleep efficiency less than 40% were excluded. The BMI, neck circumference (NC), abdominal circumference (AC) and PSG values were recorded. Results: Totally 406 patients (250 male, 156 female patients) were studied. NC was found more in males whereas AC and BMI were found significantly more in females. Mean age, apne-hypopnea index (AHI), oxygen desaturation index (ODI) for 3% were similar in two genders. Percentage of total light sleep (Stage 1+2) was significantly more in males while Stage 3 (slow wave sleep: SWS) was more in females. Total apneas were significantly more in males and hypopneas were significantly more in females. The factors associated with AHI were NC and BMI in males and AC and BMI in females. Discussion: We found that, females are more hypopneic and men are more apneic, in a study group of similar apne-hypopnea indexed patients. The different distribution of fat in genders seems to effect the apnea/hypopnea predominance. The clinical significance of the apnea and hypopnea indexes separately can be related with SWS percentage. Prospective studies are needed to evaluate the effect of apneas and hypopneas on morbidity and mortality in both genders.

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