Dergi Ara >>
Yıl:2003; Cilt: 11; Sayı: Ek 4>> Özet
Psikiyatri Psikoloji Psikofarmakoloji (3P) Dergisi; 2003;11(Ek 4):7-11
Elektrokonvulsif tedavinin etki mekanizması
C Kısa, Ç Aydemir
Ankara Numune Eğt. ve Araştırma Hastanesi Psikiyatri Kliniği
EKT’nin terapötik etkilerinin mekanizması tam olarak bilinmese de beyindeki biyokimyasal ve fizyolojik değişiklikler yoluyla olduğu kabul edilmektedir. Birbirinden farklı ruhsal bozuklukların EKT’ye iyi cevap vermesi, EKT’nin monoaminerjik iletide artış, antikonvulsan etki, nörotrofik etki, kan-beyin bariyerinin geçirgenliğinde ve serebral kan akımında artış ve başka değişik etki mekanizmaları ile açıklanmaya çalışılmaktadır. Net olarak EKT’nin çoğul etki mekanizmaları ile etki ettiği söylenebilir. Bu makalede tüm bu farklı etki mekanizmaları gözden geçirilmiştir



Mechanisms of action of electroconvulsive therapy
Although the mechanism of therapatic effect of ECT is not precisely known, it is believed that mechanism is by biochemical and physiologic changes. Response of different mental disorders to ECT is tried to explained by mechanisms like increased monoaminergic flow, anticonvulsan effect, neurotrophic effect, increased permeability of blood-brain barier and cerebral blood flow and other mechanisms. It is clear that ECT is effective by multiple mechanisms. In this article all these mechanisms of action are rewieved.

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