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Yıl:2004; Cilt: 12; Sayı: Ek 2>> Özet
Psikiyatri Psikoloji Psikofarmakoloji (3P) Dergisi; 2004;12(Ek 2):95-114
Farmakogenetik ve gelecekte vadettikleri
H Herken
Gaziantep Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalı
Farmakogenetik, ilaçlara yanıt vermede kişiden kişiye değişen farklılıkların genetik temelini araştırır. İnsan Genom Projesi ve moleküler genetik alanındaki yakın dönemdeki gelişmeler, insan genomundaki bütün genleri, ilaç güvenliği ve etkinliğindeki çeşitliliklerle bağlantılı olarak ilaç metabolizması, ilaç hedefleri ve reseptör sonrası ikincil haberci sistemlerin genlerini de içerecek şekilde çalışmak için bulunmaz bir fırsat sunmaktadır. Farmakogenetik, klinik araştırmalar ve ilaç tedavilerinin sonuçlarındaki belirsizlikleri azaltacak ve ilaç toksisitesi riskini önemli ölçüde azaltacak rasyonel bir çatı sağlamaktadır. Bu yazıda, psikotrop ilaçlarla yapılan farmakogenetik çalışmalar ve farmakogenominin gelecekte ilaç tedavi protokollerine yapması beklenen olası katkılara değinilmiştir.
Pharmacogenetics and future perspectives
Pharmacogenetics is the study of the hereditary basis of person-to-person variations in drug response. The Human Genome Project and recent avdancements in molecular genetics now present an unprecedented opportunity to study all genes in the human genome, including genes for drug metabolism, drug targets and postreceptor secondary messenger systems, in relation to variability in drug safety and efficacy. Pharmacogenetics provides a rational framework to minimize the uncertainty in outcome of drug therapy and clinical trials and thereby should significantly reduce the risk of drug toxicity. In this article, pharmacogenetics studies done with psychotropic drugs and pharmacogenomics’ expected probable support to treatment protocols in the future were mentioned.

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