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Yıl:2004; Cilt: 5; Sayı: 2>> Özet
Türkiye Klinikleri Psikiyatri Dergisi; 2004;5(2):122-131
Şizofrenide bilişsel bozukluklar
B Kayahan, Ö Öztürk, B Veznedaroğlu
Ege Üniversitesi Tıp Fakültesi Psikiyatri AD, İZMİR
Son yıllarda şizofrenide bilişsel bozukluklara olan ilgide ve bu alanda yapılan çalışmalarda büyük artış olmuştur.
Alzheimer hastalığında patognomik olarak kabul edilen ve her hastada görülen "bellek bozukluğu" gibi "belli bir bilişsel işlev alanında bozukluk" bugüne kadar yapılan çalışmalarda şizofreniye özgü olarak tanımlanamamıştır. Şizofrenide bilişsel işlev bozuklukları yaygın ve bilişsel işlevlerin değişik alanlarındadır. Şizofrenide bilişsel bozuklukların hastalığın çekirdek belirtilerinden olduğu ve şizofreni semptomlarının veya diğer faktörlerin bilişsel bozukluklara neden olmadığı yapılan çalışmalarda gösterilmiştir.
Bilişsel bozukluklar şizofreninin en sık görülen semptomlarındandır. Şizofrenideki bilişsel bozuklukların şiddeti nörodejeneratif hastalıklardaki bilişsel bozukluklardan daha fazladır.
Yapılan çalışmalarda şizofrenide bellek işlevlerinde, faal (çalışan-işleyen) bellekte, yönetici işlevlerde ve dikkatle ilgili işlevlerde bozukluklar saptanmıştır.
Bilişsel bozukluklar şizofreninin gidişi ve sonlanışını belirleyen önemli faktörlerden biridir. Daha ağır bilişsel bozukluk gösteren hastalarda, hastalığın daha kronik gidişli olduğu, tedaviye yanıt vermediği ve psikososyal işlevsellikte bozulmanın daha fazla olduğu gösterilmiştir.

Cognitive Dysfunctions In Schizophrenia
There has been an increasing attention on cognitive dysfunctions in schizophrenia during the last decades. Therefore the studies concerning this subject have also increased. Yet there is no specific cognitive dysfunction area in schizophrenia has been found like in Alzheimer's disease. But it's shown that the cognitive dysfunctions are among the core symptoms of schizophrenia and they are not the consequence of other schizophrenic symptoms.
Cognitive dysfunctions are predominant symptoms of schizophrenia. The degree of cognitive dysfunction in schizophrenia is more than the cognitive dysfunction in neurodegenerative disorders. The studies have revealed some abnormalities in memory functions (working memory), executive functions and attention in schizophrenia.
Cognitive dysfunctions are one of the major factors which determine the course and outcome in schizophrenia. The patients who have more severe cognitive dysfunctions are shown to be unresponsive to treatment, to have more chronic course and more psychosocial dysfunctions.

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