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Yıl:2011; Cilt: 24; Sayı: 1>> Özet
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Düşünen Adam: Psikiyatri ve Nörolojik Bilimler Dergisi; 2011;24(1):80-84
Steroid ile tetiklenen bir psikoz olgusunda risperidon tedavisi
A Milanlıoğlu, M Güleç
Atatürk Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalı, Erzurum
Steroidler, gerek akut gerekse de kronik, çok çeşitli tıbbi durumların tedavisinde uzun yıllardır etkin olarak kullanılmaktadırlar. Bu ilaçların kullanımı ile ruhsal bozukluklar arasındaki ilişki, bazı iyi bilinen yan etkilere rağmen, yeterince kurulmamış ve belgelenmemiştir. Yakın zamanda optik nevrit tanısı almış, steroid ile tetiklendiği düşünülen psikotik semptomlara sahip olan 46 yaşındaki bir erkek olguyu tanımlıyoruz. Ruhsal belirtiler steroidin ilk dozu sonrasında ortaya çıkmış ve steroid ile tetiklenen psikoz tanısı konulmuştur. Steroid tedavisi kesildikten sonra ruhsal belirtilerde düzelme olmamış, ancak 4 haftalık risperidon tedavisinden sonra hasta tümüyle iyileşmiştir. Bu olgu, optik nevritli hastalarda steroid ile tetiklenen ruhsal belirtiler görülmesine dair sayıca az, ancak giderek artmakta olan kanıtlara bir ektir. Bu görüngünün yaygınlığının güncel literatürde bildirilenden daha fazla olabileceğini düşünüyoruz.
Risperidone treatment in a steroid-induced psychosis case
Steroids have been used effectively for many [year]s to treat a wide variety of both acute and chronic medical conditions. Despite some well-known side effects, the association of psychiatric disorders with the use of these drugs has not been well established and documented. We describe a case of a 46- [year]-old man with a recent diagnosis of optic neuritis, who has psychotic symptoms which appear to be induced by steroids. Psychiatric symptoms emerged after the first dose of steroid and diagnosis of steroid-induced psychosis was made. After discontinuation of steroid therapy, psychiatric symptoms did not improve. But after four weeks of risperidone treatment, he recovered completely. This case adds to small but progressive body of evidence supporting the incidence of steroid-induced psychiatric symptoms in patients with optic neuritis. We suggest that the prevalence of this phenomenon might be considerably higher than what has been reported in the current literature.

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