Dergi Ara >>
Yıl:2008; Cilt: 2; Sayı: 3-4>> Özet
TAM METİN
Psikiyatride Derlemeler, Olgular ve Varsayımlar (RCHP); 2008;2(3-4):21-26
Kronik Lityum Zehirlenmesine Bağlı Koreoatetoz
A Tiryaki, E Özkorumak, İ Ak
Karadeniz Teknik Üniversitesi Tıp Fakültesi, Psikiyatri Anabilim Dalı,
Lityum (Li) uzun yıllardır çeşitli psikiyatrik tedavilerde kullanılmaktadır. Li'nin dar terapötik aralığı yüksek dozların
kullanımını kısıtlamaktadır. Li zehirlenmesi, gastroenterit benzeri belirtilerden birçok organı tutan özellikle nörolojik
belirtilere kadar uzanan klinik görüntüyle karşımıza çıkabilir. Li zehirlenmesi ile oluşan koreatetoz olguları yazında
yer almasına rağmen, ek risk etmenlerinin olmadığı, antipsikotik ilaçlarla kombine edilmeyen olgu sayısı ise azdır.
Bu olguda, Li zehirlenmesine bağlı olarak aniden gelişen koreoatetoik hareket bildirilmiştir. Acil başvurudan 1
ay önce Li dozu iki katına çıkarılan hastada önce tremor sonrasında dozun düşürülmesine rağmen her iki üst
ekstremiteyi içeren koreoatetoik hareketler gelişmiştir. Ani ortaya çıkan koreoatetoik hareketler için yükseltilen Li
dozu dışında neden bulunmamıştır. Bu olgu sunumu ile Li tedavisi sırasında oluşabilecek zehirlenme tablosu,
başta yaş olmak üzere risk etmenleri ve özellikle nörolojik bulgular bakımından tartışılmıştır.
Choreoathetosis Due To Chronic Lithium Intoxication
Lithium (Li) has been used in various psychiatric disorders for many [year]s. Its narrow therapeutic index limits its
use at high doses. Lithium intoxication may present in many forms: from clinical picture including gastroenteritis
like symptoms to various organ dysfunction predominantly neurological symptoms Although choreathetosis
related with lithium intoxication is documented in literature, cases without additional drugs and not combined
with antipsychotics are rare. Acute choreathetosis due to Li intoxication is presented in this case. Choreathetosis
including upper extremity develops despite reduction of dose upon ocurring tremor in a patient with doubling
of Li dose before admission. No reason is found except increasing dose of Li. Intoxication during Li treatment is
discussed in terms of risk factors predominantly age and neurological manifestations.

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