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Yıl:2008; Cilt: 10; Sayı: 3>> Özet
Türkiye'de Psikiyatri; 2008;10(3):79-88
Paranoid Şizofreni, Paranoid Olmayan Şizofreni ve Paranoid Bozuklukta Yürütücü İşlevler
S Yeşilyurt, F Maner, E Ceylan, J Güler, A Türkcan, N Satmış
Bağcılar Devlet Hastanesi
Amaç: Paranoid şizofreni ile paranoid bozukluk hastalarının, paranoid şizofreni olmayan ve sağlıklı kontroller
ile yürütücü işlevleri açısından karşılaştırılması amaçlanmıştır.
Yöntem: Çalışma grupları 31 paranoid ve 31 paranoid olmayan şizofreni, 37 paranoid bozukluk ve 34
sağlıklı kontroldan oluşmaktadır. Çalışma grubunun tümü 18-65 yaş arasındaki erkeklerdir. Çalışmaya katılanlara
yarı yapılandırılmış sosyodemografik bilgi formu, PANSS, yürütücü işlevleri değerlendiren İz Sürme Testi
(Trail Making Test A-B) Stroop Renk Testi, Wisconsin Kart Eşleştirme Testi, Sözel Akıcılık Testi ve Ardışık
Kategori Adlandırma Testi uygulanmıştır. İstatistiksel analizler GraphPad Prisma V.3 paket programı ile yapılmıştır.
Tek yönlü varyans analizi (ANOVA) ,Tukey çoklu karşılaştırma testi, bağımsız t testi, ki-kare testi, Pearson
korelasyon testi kullanılmıştır.
Bulgular: Paranoid bozukluk, paranoid şizofreni, paranoid olmayan şizofreni grupları İz Sürme A ve B testlerini
sağlıklı gruba göre daha uzun sürede testi tamamlamışlardır. Sözel akıcılığı değerlendiren testlerde
paranoid bozukluk ile paranoid ve paranoid olmayan şizofreni arasında farklılıklar saptanmıştır. Stroop Renk
testinin bazı bölümlerini paranoid bozukluk hastaları daha kısa sürede tamamlamakla birlikte hata ve düzeltme
sayılarında şizofreni alt gruplarına göre anlamlı farklılık saptanmamıştır. Wisconsin Kart Eşleştirme testinde
paranoid bozuklukta perseveratif olmayan hata sayısı ve ilk kategoride kullanılan deneme sayısı paranoid
şizofreniden belirgin olarak daha azdır. Paranoid bozukluk grubunun toplam yanlış ve doğru sayıları
sağlıklı gruba benzer bulunmuştur. Paranoid bozukluk grubunun toplam yanlış ve doğru sayıları şizofreni
gruplarına göre daha düşüktür. Persevaritif tepki, perseveratif hata sayısı ve yüzdesi paranoid bozukluk
ve paranoid şizofrenide benzer olup, sağlıklı gruba göre daha yüksektir. Ancak en yüksek değerler paranoid
olmayan şizofrenidedir.
Sonuç: Çalışmamızda paranoid bozukluk ve şizofreni alt grupları arasında yürütücü işlevlerin sağlıklı kontrol
grubuna göre bozulduğu saptanmıştır.
Executive Functions in Paranoid Schizophrenia, Nonparanoid Schizophrenia and Paranoid Disorder
Objective: It is aimed to investigate and compare the executive functions of paranoid disorder and paranoid schizophrenia with nonparanoid
schizophrenia and healthy controls.
Method: The sample was composed of 31 paranoid, 31 nonparanoid schizophrenia, 37 paranoid disorder patients and 34 healthy controls
with the age range 18-65. Sociodemografical form, PANSS, Trail Making Test A-B, Stroop Color Test, Wisconsin Card Sorting Test (WCST), Verbal
Fluency Test, Consecutive Categorizing Test were applied to assess the executive functions. For statistical analysis GraphPad Prisma V.3 packed
were administrated. ANOVA, Tukey multipl comparative test, t-test, chi square test, Pearson correlation test were used.
Results: Paranoid disorder, paranoid schizophrenia, nonparanoid schizophrenia groups completed Trail Making A-B Tests for long time than
healthy controls. There were differences in verbal fluency tests among paranoid disorder, paranoid schizophrenia and nonparanoid schizophrenia
groups. Although paranoid disorder group completed some of the sections of Stroop Color Test in a shorter time, there was no statistically
significance in the number of error and correction according to schizophrenia groups. The number of nonperseveratif error and trial for
the first category in Wisconsin Card Sorting Test (WCST) were significantly less among paranoid disorder than paranoid schizophrenia. Total of
wrong and right answers in paranoid disorder were similar to healthy control groups but lower than schizophrenia groups. Perseveratif reaction,
number and percentage of perseveratif error were similar in paranoid disorder and paranoid schizophrenia whereas higher than healthy
control group. The highest scores were found in nonparanoid schizophrenia.
Conclusion: In this study it was found that the executive functions of paranoid disorder and schizophrenia groups were worse than healthy
controls.

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