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Yıl:2007; Cilt: 44; Sayı: 2>> Özet
TAM METİN
Nöropsikiyatri Arşivi; 2007;44(2):77-79
Alkole Bağlı Rabdomyoliz ve Akut Böbrek Yetmezliği Olgusu
B Danışmant, Ö Saatçioğlu, E Gültürk, F Borlu, D Çakmak
Bakırköy Prof.Dr. Mazhar Osman Ruh Sağlığı ve Sinir Hastalıkları Eğitim ve Araştırma Hastanesi, İstanbul
Rabdomyoliz, düz kas hasarının olduğu yaşamı tehdit eden ciddi bir durumdur. Rabdomyolize bağlı akut böbrek yetmezliği; kapsamlı tanımlanmış olup temel patofizyolojik mekanizmaları; böbrek vazokonstrüksiyon, intraluminal biçimde değişiklikler ve direk myoglobin toksisitesidir. Bu yazıda; 46 yaşında, 20 yıldır alkol kullanım öyküsü bulunan, aşırı miktarda alkol alımı sonrası konfüzyon ve anurisi olan, rabdomyoliz ve akut böbrek yetmezliği tanısı konan bir hasta sunulmuştur. Hastanın oligürisi olup, serum kreatinini 5,1 mg/dl ve üresi 144 mg/dl (kreatinin kinaz aktivitesi: 62938 IU/dl) idi. Başlangıç tedavisinde, sıvı replasmanı yapıldı. Dört kez hemodiyaliz sonrası, böbrek fonksiyonlarında kısmi düzelme olduğu saptandı. Bu yazıda; bu olgu bağlamında yüksek doz alkol alımına bağlı rabdomyoliz ve akut böbrek yetmezliği hakkındaki literatür gözden geçirilmiştir.
A Case of Alcohol Related Rhabdomyolysis and Acute Renal Failure
Rhabdomyolysis is a severe and life-threatening condition in which skeletal muscle is damaged. Acute renal failure due to rhabdomyolysis has been widely described and its main pathophysiological mechanisms are renal vasoconstriction, intraluminal cast formation and direct myoglobin toxicity. The case of 46 [year]s old male with confusion and anuria, and diagnosed as rhabdomyolysis and acute renal failure after alcohol abuse is presented and discussed in this paper. He was oliguric and had serum creatinine and urea levels of 5.1 mg/dl and 144 mg/dl, (creatine kinase activity of 62938 IU/l) respectively. The diagnosis of rhabdomyolysis was made through clinical and laboratory findings. The initial treatment consisted of fluid replacement and forced diuresis. Partial recovery of renal function was recorded, after four hemodialysis sessions. Complete recovery was observed after two [month]s of follow-up. The related literature is reviewed in the context of the case.

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