Dergi Ara >>
Yıl:2006; Cilt: 17; Sayı: 2>> Özet
TAM METİN
Türk Psikiyatri Dergisi; 2006;17(2):101-106
Alopesi Areata ve Aleksitimi
AC Yazıcı, AD Başterzi, ŞT Acar, D Üstünsoy, G İkizoğlu, D Demirseren, A Kanık
Mersin Ü Tıp Fak.,Mersin
Amaç: Alopesi areata (AA) patogenezinde psikolojik faktörlerin rolü olduğu ileri sürülmektedir. Fakat stres verici yaşam olaylarının AA etyopatogenezindeki rolü belirsizdir. Anksiyete ve duygulanım bozukluklarının AA’lı hastalarda arttığını bildiren çalışmalar yanında, bu görüşe ters çalışma sonuçları da vardır. Bu çalışmada, stres verici yaşam olayları ve diğer psikolojik faktörlerin AA’nın etyopatogenezindeki rolünün belirlenmesi amaçlanmıştır.

Yöntem: Polikliniğimize başvuran 17’si kadın, 26’sı erkek toplam 43 AA’lı hasta ile yaş ve cinsiyet özellikleri hasta grubu ile uyumlu, 25’i kadın, 28’i erkek 53 sağlıklı birey kontrol grubu olarak çalışma kapsamına alındı. Kontrol grubu hastane personeli ve yakınlarından seçildi. Hastalar ve kontrol grubu Hastane Anksiyete ve Depresyon Ölçeği, Stres Ölçeği ve Toronto Aleksitimi Skalası (TAS) ile değerlendirildi.

Bulgular: Stres verici yaşam olayları, depresyon ve anksiyete total puanları göz önüne alındığında hasta ve kontrol grubu arasında istatistiksel olarak anlamlı bir fark saptanmadı (p>0.05). Sadece TAS’nın AA hastalarında anlamlı derecede yüksek olduğu gözlendi (p=0.013).

Sonuç: Çalışmamız, stres verici yaşam olayları, depresyon ve anksiyetenin AA etyopatogenezinde rol oynadığını desteklemedi. Fakat AA’nın aleksitimi ile ilişkisini ortaya çıkardı. Aleksitiminin immün fonksiyonlarda bozulmaya neden olduğu ve aleksitimik bireylerin psikolojik, endokrin ve immün sonuçları olan fark etmedikleri bir kronik strese maruz kaldıkları ileri sürülmüştür. Bu nedenle biz, aleksitiminin stresle başa çıkmayı güçleştirip, stresle tetiklenen immünolojik mekanizmalar aracılığıyla AA’yı ortaya çıkarabileceğini düşünmekteyiz.
Alopecia Areata and Alexithymia
Objective: Whether or not psychological factors play an important role in the pathogenesis of alopecia areata (AA) is a controversial issue. AA has had a tendency to be associated with high avoidance in attachment relationships, high alexithymic characteristics, and poor social support. Some studies have suggested that personality characteristics might modulate individual susceptibility to AA. The role of stressful life events in the appearance of AA is uncertain. In addition to reports associating anxiety and affective disorders with the onset of AA, there have also been studies that have not confirmed such an association. This case-control study was undertaken with the aim of determining the significance of stressful life events and other psychological factors in the etiopathogenesis of AA.

Method: A total of 43 patients (26 male, 17 female) with AA and 53 age-and gender-matched healthy controls selected from hospital staff and their relatives (28 male, 25 female) were enrolled in the study. Both patients and controls were evaluated using the Hospital Anxiety and Depression Scale (HADS), Stress Scale, and Toronto Alexithymia Scale (TAS).

Results: There was no statistically significant difference between the patient and control groups with regard to the total scores of stressful major life events, depression, and anxiety (p>0.05). However, TAS scores in patients with AA were higher than in controls (p=0.013).

Conclusion: The present study found no evidence that stressful major life events, depression, or anxiety have a role in the etiopathogenesis of AA, but AA tended to be associated with alexithymia. It has been suggested that alexithymics may suffer from unnoticed chronic stress with physiological, endocrine, and immune consequences, and that alexithymia is associated with impaired immune response. We suggest that alexithymia may play a role in the pathogenesis of AA via stress-induced immunological mechanisms.

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