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Yıl:2020; Cilt: 33; Sayı: 2>> Özet
TAM METİN
Düşünen Adam: Psikiyatri ve Nörolojik Bilimler Dergisi; 2020;33(2):206-209
Özofagus perforasyonu ve normoglisemik keton pozitifliği bulunan hiperemezis gravidarum tedavisinde mirtazapinin hızlı etkinliği: Olgu sunumu
A T Kul, İ Gündoğmuş, M B Aydın
Health Science University, Ankara
Hiperemezis gravidarum, fetüs ve anne için ciddi sonuçlara neden olabilecek tıbbi bir durumdur. Şiddetli ve tedaviye dirençli olan hastalarda tedavi rejimleri belirsizdir. Antiemetiklerin literatürde hiperemezis gravidarum için kullanıldığı bilinmesine rağmen, mirtazapin bazı tedaviye dirençli vakalarda etkili bir şekilde kullanılmıştır. Diğer yandan, bildiğimiz kadarıyla, literatürde şiddetli ve tedaviye dirençli hiperemezis gravidarum vakalarında mirtazapinin etkinliği hakkında rapor bildirilmemiştir. Bu vakanın amacı, şiddetli ve tedaviye dirençli hiperemezis gravidarum nedeniyle özofagus perforasyonu ve normoglisemik keton pozitifliği gelişen 28 yaşında bir gebe hasta için mirtazapin ile başarılı tedavisini sunmaktı. Vaka mirtazapinin şiddetli hiperemezis gravidarum vakalarında bile etkili olabileceğini göstermiştir. Ek olarak, mirtazapinin hiperemezis gravidarum tedavisinde etkinliği bir kez daha gösterilmiştir. Bununla birlikte, mirtazapinin hamile hastaların tedavisinde kullanılabileceği gerçeği tartışılabilir.
Rapid efficacy of mirtazapine in the treatment of hyperemesis gravidarum with esophagus perforation and ketonuria in a normoglycemic patient: a case report
Hyperemesis gravidarum is a medical condition that may cause serious consequences for fetus and mother. The treatment regimen in patients with severe and treatment-resistant conditions is unclear. While antiemetics are known to be used for hyperemesis gravidarum in the literature, mirtazapine has been used effectively in some treatment-resistant cases. On the other hand, to the best of our knowledge, no reports on the efficacy of mirtazapine in cases of severe and treatment-resistant hyperemesis gravidarum have been published in the literature. The aim of our report was to present a successful treatment with mirtazapine for a 28-year-old pregnant patient who developed esophageal perforation and ketonuria while being normoglycemic due to severe and treatment-resistant hyperemesis gravidarum. This case revealed that mirtazapine may be effective even in severe cases of hyperemesis gravidarum. In addition, the effectiveness of mirtazapine in the treatment of hyperemesis gravidarum has been confirmed. However, the appropriateness of using mirtazapine in the treatment of pregnant patients needs to be discussed.

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