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Yıl:2020; Cilt: 33; Sayı: 1>> Özet
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Düşünen Adam: Psikiyatri ve Nörolojik Bilimler Dergisi; 2020;33(1):50-58
Opioid bağımlılığı olan erkek bireylerde temiz kalma sürelerine göre bilişsel işlevlerin değerlendirilmesi
B Koparal, CO Yanık, IV Sahiner, HA Kaloglu, MH Aksu, C Utku, Z Arikan
Rize Recep Tayyip Erdoğan Üniversitesi, Rize
Amaç: Opioid bağımlılığı, tekrarlayan opioid kullanımı veya kompülsif arama davranışı ile karakterize bir nöro-davranışsal bozukluktur. Bu çalışmada, bilişsel işlevlerin temiz kalma sürelerine göre değerlendirilmesi ve bilişsel işlevleri etkileyen diğer faktörlerin değerlendirilmesini amaçladık. Yöntem: Çalışma Şubat 2017- Nisan 2017 tarihleri arasında Gazi Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalı'nda gerçekleştirildi. Çalışmaya detoksifikasyon tedavisini tamamlamış ve idame tedavisi almakta olan toplam 96 erişkin erkek katıldı. Hastalar temiz kalma sürelerine göre üç gruba ayrıldı. İlk olarak sosyodemografik veri formu ve Beck Anksiyete Envanteri uygulandı. Daha sonra Wisconsin Kart Eşleme Testi, Rey İşitsel-sözel Öğrenme Testi ve Stroop Testi uygulandı. Bulgular: Bilişsel işlevler açısından norm değerlerle karşılaştırıldığında örneklem grubunda anlamlı bir bozulma olmadığı saptandı. 0-3 ay arası temiz olan hasta grubunda, 1 yıldan daha uzun süre temiz kalma süresi olanlara göre daha iyi bellek skorları mevcuttu. Ayrıca çoklu madde kullanım süresinin, ilk madde kullanım yaşının ve tedavi sayısının bazı bilişsel işlevleri olumsuz yönde etkilediğini bulundu. Sonuç: Bu çalışma, Türkiye'de opioid bağımlılığı olan erkeklerde bilişsel işlevlerin değerlendirildiği ilk çalışmadır. Bilişsel işlevleri etkileyen tüm faktörleri kontrol etmek mümkün değildir. Bu nedenle, opioidlerin etkisinin özel olarak incelenebildiği, ileriye dönük çalışmalara ve hayvan çalışmalarına ihtiyaç vardır.
Cognitive functions in opioid-dependent males according to duration of abstinence
Objective: Opioid dependence is a neurobehavioral disorder characterized by repeated compulsive craving or using an opioid. In this study, we aimed to evaluate cognitive functions according to the duration of abstinence and other factors affecting cognitive functions. Method: The study was carried out between February and April 2017 at the Psychiatry Department of Gazi University Medical Faculty. A total of 96 adult males participated; all of them had received detoxification treatment and were undergoing maintenance treatment. Patients were divided into three groups according to the duration of abstinence. First, a sociodemographic data form and Beck Anxiety Inventory were administered. Afterwards, the Wisconsin Card Sorting Test, Rey Auditory-Verbal Learning Test, and Stroop Test were applied. Results: The sample group showed no significant impairment in their cognitive functions when compared to the norm values. The group of patients with 0-3 months of abstinence had higher memory scores than those who had been abstinent for more than 1 year. We also found that duration of multiple substance use, age of first substance use, and the number of treatments undergone affected some of the cognitive functions negatively. Conclusion: This study is the first in which cognitive functions have been evaluated in opioid-dependent males in Turkey. It is not possible to control all of the factors affecting cognitive functions. Therefore, prospective studies and animal studies in which the effect of opioids can be examined exclusively are needed.

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