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Yıl:2018; Cilt: 5; Sayı: 2>> Özet
TAM METİN
Türk Uyku Tıbbı Dergisi; 2018;5(2):54-57
Uyku ve Açık Bellek Arasındaki İlişki
NT Yazıhan, S Yetkin
Çankaya Üniversitesi, Ankara,
Uyku fizyolojik olarak aktif bir süreç olup bilişsel süreçlere ilişkin fonksiyonu uzun zamandır bilinmektedir. Uykunun iki farklı aşamada bellek ile ilişkili olarak kritik olduğu bilinmektedir. Birincisi öğrenme öncesi olan bilginin kodlanması aşaması; ikincisi ise öğrenme gerçekleştikten sonra yeni bilgilerin kalıcılığıyla ilişkili olan konsolidasyon aşamasıdır. Konsolidasyonun belleğin pek çok formu için evrimsel olarak korunmuş uykunun bir fonksiyonu olduğu düşünülmektedir. Bu derleme yazısının amacı uykunun mikro ve makro yapıları ile açık-deklaratif bellek süreçlerinin ilişkisini araştıran başlıca çalışma bulgularını bir araya getirmektir. Öncelikle uyku tanımlanmış, sonrasında uykunun açık bellek konsolidasyonu sürecindeki özgün rolü açıklanmıştır. Bu bağlamda öne sürülen aktif sistem konsolidasyonu ve sinaptik homeostazis hipotezleri anlatılmıştır. Uyku deprivasyonunun açık bellek ve bilgi işleme süreçleri üzerine etkilerini araştıran çalışma sonuçları özetlenmiştir. Son olarak uykunun mikro yapısını oluşturan uyku iğciği ve yavaş dalga aktivitesinin bellek süreçleri üzerindeki rolü tartışılmıştır.
The Relationship Between Sleep and Declarative Memory
Sleep is a physiologically active process and the function of cognitive processes is known for a long time. It is also known that sleep has a crucial role in two distinct phases of memory. The first one is the information encoding phase which is prior to the learning process; and the second one is the consolidation phase which is related with the persistency of new information after learning occurs. Consolidation is thought as a function of evolutionarily preserved sleep for many forms of memory. The aim of this review is to get together the main study findings which investigating the relationship between the micro and macro structures of sleep and declarative memory processes. Firstly, definition of sleep is given, and then the specific role of sleep in declarative memory consolidation process is explained. In this context, the projected active system consolidation and synaptic homeostasis hypothesis are explicated. The study results investigating the effects of sleep deprivation on declarative memory and information processing phases are summarized. Finally, the role of sleep spindle and slow wave activity on memory processes, which make up the microstructure of sleep, is discussed.

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