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Yıl:2017; Cilt: 4; Sayı: 3>> Özet
TAM METİN
Türk Uyku Tıbbı Dergisi; 2017;4(3):76-83
Obstrüktif Uyku Apne Sendromunda Kognitif Fonksiyonların Objektif ve Subjektif Testlerle Değerlendirilmesi
AK Ak, ÜS Sarı, B Oktan, T Korkmaz, GD Horasan, D Selçuki, H Yılmaz
Celal Bayar Üniversitesi, Manisa
Amaç: Obstrüktif solunumla ilgili olarak uyku sırasında ortaya çıkan birincil ve ikincil sonuçlar, indirekt olarak bilişsel, duygusal ve davranışsal değişikliklere neden olmaktadır. Bu çalışmada; uyku laboratuvarında ağır Obstrüktif Uyku Apnesi sendromu (OUAS) teşhisi konulan hastaların başlangıç ve tedavi aşamasındaki uyku kalitesinin ve uyku kalitesi ile bilişsel fonksiyonlar arasındaki ilişkinin değerlendirilmesi amaçlanmaktadır. Gereç ve Yöntem: Hastaların dikkatlerinin değerlendirilmesi için Pittsburg, Epworth ve Stroop testi; hafıza ve dikkatlerinin değerlendirilmesi için P300 testi uygulanmıştır. Bulgular: Hastaların tedavi öncesi ve tedavi sonrası bilişsel işlevleri karşılaştırıldığında; tedavi sonrası gündüz uyuklamasında önemli bir azalma olduğu (p=0,000) ve P300 testi latansında belirgin düzelme olduğu (p=0,000-p=0,001-p=0,004) görülmüştür. Pittsburgh çalışmasında; tedavi öncesi toplam uyku kalitesi skorları, uyku kalitesinin kötü olmasıyla uyumlu iken, tedavi sonrası elde edilen ortalama değer ise uykunun sağlıklı olmasıyla ilişkili bulunmuştur (p=0,000). Dikkati ölçmek için yapılan Stroop testinde tedavi sonrasında elde edilen hata düzeltme oranının önemli biçimde düzeldiği görülmüştür (p=0,010). Sonuç: Ağır OUAS tanısı konulan hastalarda; hastalığın dikkat, uyanıklık ve hafıza üzerindeki olumsuz etkileri, dikkati sürdürme konusunda yaşanan zorluklar ve bunların uyku yapısı üzerindeki olumsuz etkileri, diğer yayınlardan farklı olarak; Stroop, Pittsburgh, P300 ve Epworth testleriyle ortaya konulmuştur. Tedavi sonrasında yapılan testlerin sonucunda, hastalıkta önemli bir gelişme olduğunun ortaya konulması, tedavinin ne denli önemli ve gerekli olduğunu bize göstermektedir.
Evaluation of Cognitive Function Using Objective and Subjective Tests in the Obstructive Sleep Apnea Syndrome
Objective: The primary and secondary consequences which related to obstructive respiration to occur during sleep cause cognitive, emotional and behavioral changes indirectly. Aim of the present study was to evaluate quality of sleep and relationship between quality of sleep and cognitive function at baseline and during treatment in the patients having diagnosis of severe Obstructive Sleep Apnea syndrome (OSAS) being followed in sleep laboratory. Materials and Methods: Pittsburg, Epworth and Stroop tests to assess patient attention; P300 test was applied for the evaluation of memory and attention. Results: When the pre-treatment and post-treatment cognitive functions of the patients were compared; there was a significant decrease in daytime sleepiness after treatment (p=0.000) and a significant improvement in latency of P300 test (p=0.000-p=0.001-p=0.004). In Pittsburgh study; the pre-treatment total sleep quality scores were consistent with poor sleep quality, while the mean value obtained after treatment was found to be related to the healthy sleepiness (p=0.000). In the Stroop test for measuring attention, the rate of error correction obtained after treatment was significantly improved (p=0.010). Conclusion: In patients diagnosed with severe OSAS; the negative effects of disease on attention, alertness, and memory, challenges on maintaining the attention and its negative effects on the structure of sleep has been shown by using Stroop, Pittsburgh, P300 and Epworth tests unlike other publications. As a result of the tests performed after the treatment, the fact that it is an important development in the disease shows us how the treatment is important and necessary

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