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Treatment compatibility is crucial for the psychiatric disorders. This can be provided with the low side effect profile of psychotropic drugs. Aripiprazole, a tolerable and safe antipsychotic, is used in the treatment of various psychiatric disorders. In the previous studies, sialorrhea was declared as a side effect of some antipsychotics. Furthermore, aripiprazole-related sialorrhea which was treated with diphenhydramine and trihexyphenidly, was reported in the literature. In our case, we discussed that aripiprazole-related sialorrhea developed in a male patient who treated with amitriptyline.