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Yıl:2012; Cilt: 15; Sayı: 1>> Özet
TAM METİN
Klinik Psikiyatri Dergisi; 2012;15(1):26-32
Bir Psikiyatri Kliniğinde Yatarak Tedavi Gören Geç Başlangıçlı Şizofreni Hastalarının Klinik ve Sosyodemografik Özellikleri
Ö Saraçlı, HO Keser, N Atasoy, İ Kaygısız, A Atalay, Ü Öztürk, L Atik
Zonguldak Karaelmas Üniversitesi, Psikiyatri Anabilim Dalı, Zonguldak
Amaç: Geç başlangıçlı şizofreni hastalarının kliniğinde, şizofreni hastalarına benzer şekilde paranoid sanrılar, kötülük görme sanrıları ve işitsel halüsinasyonlar görülür fakat duygulanımda küntleşme, negatif belirtiler ve ailede şizofreni öyküsü daha azdır. Bu çalışmanın amacı kliniğimizde yatarak tedavi gören geç başlangıçlı şizofreni hastalarının klinik özellikleri ve tedavi yanıtlarının gözden geçirilmesidir. Yöntem: 2001-2010 yılları arasında Karaelmas Üniversitesi Tıp Fakültesi psikiyatri kliniğinde tedavi gören 26 geç başlangıçlı şizofreni hastasının sosyodemografik özellikleri, DSM-IV tanıları, klinik özellikleri, hastalığın başlamasından bu yana geçen süre, hastanede yatış süresi, tedavide kullanılan ilaçlar ve tedavi yanıtı, vitamin B12 ve folik asit kan düzeyleri ve görüntüleme tekniklerinin sonuçları yatış dosyaları taranarak kaydedildi. Bulgular: Hastaların yaş ortalaması 54.2±6.25 (45-69), 15'i (%57.7) erkek, 11'i (%42.3) kadın, hastalık başlangıç yaşı ortalaması 41.8±2.4 (40-48) bulundu. Hastaların %85'inde sanrı, %46'sında halüsinasyon, %30'unda ajitasyon, %27'sinde apati ve %12'sinde bilişsel sorun vardı. Beyin görüntüleme yapılmış 17 hastadan 8'inde yapısal sorunlar bildirilmişti. Hastaların %54'ünde B12 eksikliği, %4'ünde folik asit eksikliği mevcuttu. Sonuç: Geç başlangıçlı şizofreni hastalarında beyin görüntüleme ve diğer tıbbi değerlendirmeleri yapmanın önemli olduğunu düşünüyoruz. Bu durumun epidemiyoloji, fenomenoloji, genetik, biyolojik ve psikososyal yönü, süreç ve sonucunu daha iyi anlamak için daha ileri çalışmalara ihtiyaç vardır.
The Clinical and Sociodemographic Features of Late Onset Schizophrenia Patients in a Psychiatry Clinic
Objective: The late onset schizophrenia patients had
symptoms similar to those of schizophrenia patients like
paranoid delusions, persecutory delusions and auditory
hallucinations but with less affective flattening, negatif
signs and family history of schizophrenia. The purpose of
this paper was overwiew the clinic features and treatment
response of late onset schizophrenia patients.
Method: We collected data about sociodemographic
features, DSM-IV diagnosis, clinic features, period of disease,
inpatient periods, medication and treatment
response, blood levels of vitamin B12 and folic asid,
imaging technique results of 26 late onset schizophrenia
patients that was treated in Psychiatry Clinic of
Karaelmas University from 2001 to 2010. Results: The
mean age of patients was 54.2±6.25 (range: 45-69), 15
(57.7%) were male, 11 (42.3%) were female. The mean
age of onset was 41.8±2.4 (range: 40-48). Delusions
were present in 85%, hallucinations were present in
46%, ajitation were present in 30%, apathy were present
in 27% and cognitif problems were present in 12% of
the patients. The structural abnormalities were present
in 8 of 17 patients who had brain imaging. The patients
who had abnormal imaging results have longer inpatient
periods. The vitamin B12 and folic asid deficiency were
present in 54% and 4% of the patient, respectively.
Conclusion: It is important that doing brain imaging
and other medical assesments in the late onset schizophrenia.
Further systematic research into its epidemiology,
phenomenology, genetics, biological and psychosocial
issues, course and outcome are necesary for a beter
understanding of this condition.

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