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Yıl:2011; Cilt: 1; Sayı: 2>> Özet
TAM METİN
Journal of Mood Disorders; 2011;1(2):72-74
Mizaç bozuklukları açısından aile öyküsü bulunan bir hastada amoksisilin kullanımına bağlı ikincil akut mani
B Bakım, G Alpak, HS Şengül, N Kahraman, O Tankaya, KO Karamustafalıoğlu
Şişli Etfal Eğitim ve Araştırma Hastanesi, İstanbul
Antimikrobiyal ajanların yan etkisi olarak gelişen manik reaksiyonlarla ilgili literatür birkaç olgu sunumu ile sınırlıdır. Biz burada aile öyküsünde mizaç bozukluğu olan antibiyotik kullanımına bağlı ikincil bir mani olgusu sunuyoruz. Bir hafta amoksisilin uygulanmasının ardından akut manik psikoz geliştiren 16 yaşında bir olgu bildiriyoruz.

Hasta lityum ve risperidon ile tedavi edildi. Bir mizaç düzenleyici ve antipsikotikle tedavisinin ilk haftasında hastanın Kısa Psikiyatrik Değerlendirme Ölçeği ve Young Mani Değerlendirme Ölçeği puanlarında azalma gözlendi ve hasta taburcu edildi. Antibiyotikler aile öyküsü bulunan bireylerde bir mizaç bozukluğunu tetikleyebilir ve antibiyotiğin kesilmesi belirtilerin azalması için yeterli olmayabilir. Mizaç düzenleyiciler ve diğer antimanik ajanlara genellikle ihtiyaç duyulur.
Acute secondary mania due to amoxicillin use in a patient with family history of mood disorders
The literature about manic reactions as side effects of antimicrobial agents is restricted to a limited number of case reports. We here present a secondary mania case due to antibiotic use with a positive family history for mood disorders. We report the case of a 16- [year]-old patient developed an acute manic psychosis after 1 week administration of amoxicillin. Patient was treated with lithium and risperidone. In the first week of the treatment with mood stabilizer and an antipsychotic patient’s Brief Psychiatric Rating Scale and Young Mania Rating Scores decreased and patient was discharged. Antibiotic agents may trigger a mood disorder in individuals with a positive family history and discontinuation of the antibiotic agent may not be enough to alleviate the symptoms. Mood stabilizers and other antimanic agents are frequently needed.

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