Dergi Ara >>
Yıl:2011; Cilt: 48; Sayı: 2>> Özet
TAM METİN
Nöropsikiyatri Arşivi; 2011;48(2):162-163
Major Depresyonlu Hastada Mirtazapine Bağlı, Geri Dönüşümlü Hepatotoksisite
T Dumlu, F Canan, G Celbek, A Güngör, Y Aydın
Düzce Üniversitesi Tıp Fakültesi, Düzce
Mirtazapin, major depresyon tedavisinde onay almış, noradrenerjik ve spesifik serotonerjik bir antidepresandır. Sersemlik, aşırı sedasyon, iştahta artma, kilo alımı ve ağız kuruluğu gibi yan etkileri olabilmesine karşın genellikle iyi tolere edilir. Burada, 23 yaşında depresif kadın hastada, mirtazapin tedavisi sırasında gelişen karın ağrısı ve karaciğer enzimlerinde yükselme olması ve mirtazapin kullanımı durdurulduktan sonra bulguların normale dönmesi tartışılmıştır.
Reversible Hepatotoxicity of Mirtazapine in a Patient with Major Depression
Mirtazapine is a noradrenergic and specific serotonergic antidepressant that is approved for use in the treatment of major depression. It is generally well

tolerated with some mild side effects such as drowsiness, excessive sedation, increased appetite, weight gain, and dry mouth. We present a case of 23 [year]s old female depressive patient who developed abdominal pain and elevation of liver enzymes during treatment with mirtazapine and returned to normal after stopping the mirtazapine use.

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