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Yıl:2011; Cilt: 22; Sayı: 2>> Özet
TAM METİN
Türk Psikiyatri Dergisi; 2011;22(2):123-125
Şizofrenide Polidipsi ve Hiponatremi Tedavisinde Risperidon Kullanımı Üzerine Bir Olgu Çalışması
N Rao, G Venkatasubramanian, V Korpade, R Behere, S Varambally, B Gangadhar
Ulusal Ruh Sağlığı ve Nörobilim Enstitüsü, Bangalor, Hindistan
Psikojenik polidipsi ve bununla ilişkili hiponatremi kronik psikiyatrik hastalıklarda, özellikle şizofrenide görülen ve ölümcül olabilen bir olgudur. Hastalar işbirliğinde bulunmadıklarından ve su tüketim miktarlarını sakladıklarından bu durumu fark etmek ve kontrol etmek zordur ancak oluşabilecek komplikasyonlar açısından önemlidir. Tedavi için, istemsiz sıvı kısıtlaması ve demeklosiklin, propranolol, kaptopril, nalokson gibi çeşitli farmakolojik maddelerin kullanımı gibi farklı yöntemler kullanılmıştır ve bu yöntemler çelişkili sonuçlar göstermiştir. Polidipsinin tedavisinde antipsikotikler de kullanılmıştır ancak antipsikotiklerin polidipsiyi hem iyileştirici hem de polidipsiye neden olan etkileri bildirildiğinden polidipsi tedavisinde antipsikotik kullanımının rolü kesinleşmemiştir. Tipik antipsikotikler polidipsinin alevlenmesiyle ilişkilendirilirken klozapin ise polidipsinin azalmasıyla ilişkilendirilmiştir. Negatif sonuçlar bildirildiğinden, tedavide risperidonun etkinliği tartışmalıdır. Bu çalışmada polidipsi ve hiponatremisi olan ve risperidon ile tedavi edilmiş bir şizofreni olgusu sunulmaktadır.
Risperidone Treatment for Polydipsia and Hyponatremia in Schizophrenia: A Case Report
Psychogenic polydipsia with associated hyponatremia is a potentially fatal condition observed in patients with chronic psychiatric illness, especially schizophrenia. Recognition and management of this condition are difficult, as patients are uncooperative and secretive about their water intake, but are important in terms of the associated complications. Different strategies, including involuntary fluid restriction and use of various pharmacological agents, such as demeclocycline, propranolol, captopril, and naloxone, have been used for the treatment of this condition with inconsistent results. Antipsychotics have also been used in the treatment of polydipsia; however, their role is not clear as there are reports of antipsychotics both improving and causing polydipsia. Typical antipsychotics have been associated with exacerbation of polydipsia, whereas clozapine has been associated with its improvement. The efficacy of risperidone in the treatment of this condition is controversial, as negative results have been reported. Herein we present a schizophrenia case with polydipsia and hyponatremia that was successfully treated with risperidone.

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