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Yıl:2011; Cilt: 22; Sayı: 2>> Özet
TAM METİN
Türk Psikiyatri Dergisi; 2011;22(2):65-76
Psikozlarda Gen-Çevre Etkileşimi için İzmir Akıl Sağlığı Araştırması (TürkSch): Amaç ve Yöntem
T Binbay, H Elbi, K Alptekin, FA Tanık, M Drukker, H Onay, F Özkınay, N Zağlı, J Van Os
., Sinop Atatürk Devlet Hastanesi, Psikiyatri Bl., Sinop
Amaç: İzmir büyükşehir bölgesi hanelerinde yaşayan 15-64 yaş arası bireylerden oluşan bir örneklemde psikotik bozukluklar ve belirtiler başta olmak üzere akıl sağlığı sorunlarının yaygınlığını, risk etkenlerini değerlendiren çok aşamalı bir araştırmanın amaçlarını ve yöntemini tanımlamak.
Yöntem: Araştırma üç aşama içermektedir. Yöntemi bu makalenin ana konusu olan ilk aşamada, temel tarama aracı olarak birçok DSM-IV bozukluğunun yaşam boyu ve son bir yıl yaygınlığını değerlendiren Uluslararası Bileşik Tanı Görüşmesi 2.1 kullanılmıştır. İkinci olarak, aynı yerleşim birimlerinde mahallelerin sosyal sermayesini değerlendiren paralel bir araştırma yürütülmüştür. Üçüncü olarak, genetik ve çevresel risk etkenlerini araştırmak için kesitsel araştırmanın içine yerleştirilmiş bir olgu-kontrol çalışması gerçekleştirilmiştir.
Bulgular: Toplam 4011 erkek ve kadından oluşan, 9 ilçede ve 302 idari mahallede yer alan haneleri temsil eden çok katmanlı kümeli bir örneklem ile görüşülmüştür. İlk aşamanın katılım oranı, görüşme yapılabilecek 5242 hanede %76,5?dir ve katılımcılarla 2008 yılında evlerinde görüşme yapılmıştır. Duygudurum bozuklukları (son 1 yıl), şizofreni ve diğer psikotik bozukluklar (yaşam boyu) ve psikoaktif madde kullanımı ve bağımlılığı (yaşam boyu) taranmıştır.
Sonuç: Kesitsel olmasına rağmen TürkSch'ın araştırma deseni özgündür ve yüksek kaliteli bir verinin elde edilmesini sağlamıştır. Bu da araştırmanın, akıl sağlığı hastalıklarının Türkiye nüfusundaki yaygınlığını, risklerini ve daha üst seviyedeki etkileşim özelliklerini psikoza odaklı olarak incelenmesine olanak vermiştir.
Izmir Mental Health Survey for Gene-Environment Interaction in Psychoses (TürkSch): Objectives and Methodology
Objective: To describe the objectives and design of a multistage study on the prevalence and risk factors of mental health problems, in particular psychotic disorders and psychotic symptoms, by assessing a probabilistic sample of household residents in the Izmir Metropolitan Area, aged 15-64 [year]s.
Method: The study included three different observation frames. In the first stage, of which methodology is in the focus of this paper, the primary screening instrument was the Composite International Diagnostic Interview 2.1, which assesses lifetime and/or last one [year] occurrence of several DSM-IV disorders. Second, a parallel survey of social capital of administrative wards was conducted in the same neighbourhoods. Third, a nested-case control study was performed to study effects of genetic and environmental risk factors on wide psychosis phenotype.
Results: A total of 4011 males and females were contacted through a multistage clustered area probability sample of administrative neighbourhoods and households, covering 9 districts and 302 neighbourhoods. The response rate for the first stage was 76.5% in 5242 eligible households. Respondents were interviewed at home in 2008 for the screening of included mental health problems. The screened disorders were mood disorders (last 1 [year]), schizophrenia and other non-affective psychotic disorders (lifetime), and dependence and abuse of psychoactive substances (lifetime).
Conclusion: Although cross-sectional in nature, the TürkSch has a unique study design and yields data of high quality. This enables study of the prevalence, risk and higher-order interactions underlying ill-health in the Turkish population, with a specific focus on psychosis.

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