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Yıl:2011; Cilt: 48; Sayı: 1>> Özet
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Nöropsikiyatri Arşivi; 2011;48(1):17-21
Akut Tam Uyku Yoksunluğunun Enerji Metabolizması Üzerine Etkileri
O Çalıyurt, EÇ Edis, G Altay
Trakya Üniv., Edirne
Amaç: Bu araştırmada tam uyku yoksunluğunun günlük bazal enerji tüketimlerine olası etkisinin araştırılması amaçlanmıştır. Yöntemler: Araştırmaya 20 sağlıklı gönüllü dahil edildi. Gönüllülerin dinlenme enerjileri sabah saat 09:00'da ve kahvaltı etmeden indirekt kalorimetri yöntemi ile solunumsal gaz değişimleri değelendirilerek ölçüldü (Vmax 29c Sensor Medics, Yorba Linda, CA, USA). Dinlenme enerjisi ölçümü uyanık vaziyette, 8 saatlik bir dinlenme sonrasında ve sabit oda sıcaklığında gerçekleştirildi ve en az 20 dakika ölçüm yapıldı. Bu ölçüm tam 24 saat sonra ve total uyku yoksunluğu sağlanması sonrasında tekrar edildi. Bulgular: Gönüllülerin dinlenme enerji ilk ölçüm ortalaması 1351.10±600.37 kcal/24 saat ve ikinci ölçüm ortalaması ise ilkinden daha düşük olarak 1250.60±454.39 kcal/24 saat şeklinde saptanmıştır fakat aradaki fark istatistiki anlamlılık sınırına ulaşmamıştır. Kadın ve erkeklerde ayrı ayrı değerlendirme sonrasında da dinlenme enerjisi değişimi uyku yoksunluğu öncesi ve sonrasında cinsiyetler arasında farklılık göstermedi. Vücut Kitle İndeksi ile hem ilk ve hem de ikinci ölçülen dinlenme enerjileri arasında pozitif ve istatistiki olarak anlamlı bir korelasyon saptandı. Sonuç: Bu araştırma sonucunda tam uyku yoksunluğunun doğrudan günlük bazal enerji tüketimine anlamlı bir etkisinin olmadığı ortaya konulmuştur. Uyku yoksunluğu, uyku bozuklukları ve özellikle insomnia bireylerde metabolik değişiklikler ortaya çıkarmaktadır. Bu değişiklikler genellikle kilo artışı ve diyabete yol açmaktadır. Bu etkiler doğrudan enerji tüketimi ilişkili olmayıp uyku kısıtlamasının ortaya çıkardığı iştah artışı, glukoz metabolizması bozuklukları gibi diğer metabolik etkiler ve kronik süreçteki uyku kısıtlamaları ile ilişkili görülmektedir.
The Effect of Acute Total Sleep Deprivation on Energy Metabolism
Objective: The aim of the present study was to assess the effects of total sleep deprivation on daily basal energy expenditure. Methods: Twenty healthy volunteers were included in the study. Resting energy expenditure was measured with indirect calorimetry device (Vmax 29c Sensor Medics, Yorba Linda, CA, USA) at 09:00 a.m., and food was withheld after midnight the prior evening. The measurements were carried out after eight hours of rest in awake subjects at constant ambient (environmental) temperature for at least 20 minutes. After 24 hours of total sleep deprivation, the measurements were repeated. Results: The first-measured mean resting energy expenditure was 1351.10±600.37 kcal/24 h and the second measurement revealed slight decrease with a mean value of 1250.60±454.39 kcal/24 h, but the difference did not reach the level of statistical significance. The changes in mean resting energy expenditure values before and after total sleep deprivation were evaluated in men and women separately, but no significant difference was observed between the two genders. Mean body mass index values correlated positively and significantly with both first and second resting energy measurements. Conclusion: Our results showed that total sleep deprivation did not directly affect daily basal energy expenditure. Sleep deprivation, sleep disorders and insomnia are associated with metabolic changes. Those metabolic effects are more likely related to chronic sleep restriction and changes in appetite and glucose metabolism that may cause weight gain and diabetes, rather than being direct effects on energy expenditure.

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