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Yıl:2010; Cilt: 2; Sayı: 1>> Özet
Geriatri ve Geriatrik Nöropsikiyatri Dergisi; 2010;2(1):48-54
Yaşlanma ve Genetik
Y Soysal, N İmirzalıoğlu
Afyon Kocatepe Üniversitesi
Yaşlanma, genellikle yaşlı ve hasta kavramları ile ilişkilendirilmesine rağmen, yaşlanma uterusta başlayan, hastalıkla ve hayat kalitesinin bozulmasıyla mutlaka ilişkilendirilmesi gerekmeyen vücutta ilerleyici bir fonksiyon kaybıdır. Bugün, bilgilerimiz yaşlanmanın dinamik ve biçimlendirilebilir bir işlem olduğunu, gelişme ve yaşlanma zamanının sadece genlerle değil aynı zamanda çevresel ve epigenetik etkilerle kontrol edildiğini göstermektedir. Bu derlemenin amacı, yaşlanma sürecinde genetik faktörlerin ne kadar etkili veya etkisiz olduğunu değişik biyolojik yolaklarda rolü olan genlerden örnekler vererek tartışmaktır.
Ageing and genetics
Ageing is a process that starts in uterus and progressively characterised by loss of function and not necessarily mean the presence of disease and poor quality of life. Today, our knowledge of ageing demonstrates that, ageing is a dynamic and malleable process, genes not only control development and ageing time but also pointed out that environment and epigenetic factors have effects on lifespan. We aimed in this review article to discuss how genetic factors are effective or not in different biological pathways by giving examples of genes.

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