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Yıl:2010; Cilt: 47; Sayı: 3>> Özet
TAM METİN
Nöropsikiyatri Arşivi; 2010;47(3):230-236
Şizofrenide Potansiyel Risk Etkenleri
BN Akal, O Doğan
Sivas Devlet Hastanesi
Amaç: Şizofreni bireyi birçok yönden etkileyen ciddi bir mental hastalıktır. Ortaya çıkmasında birçok risk faktörü öne sürülmüştür. Bu çalışmanın amacı, hastaların özelliklerinden yola çıkarak şizofreninin potansiyel risk faktörlerini belirlemektir.

Yöntemler: Araştırmaya DSM-IV tanı ölçütlerine göre şizofreni tanısı konmuş 164 hasta ve 164 sağlıklı alınmıştır. Deneklere potansiyel risk etkenleri anket formu (doğum öncesi ve sonrası, sosyodemografik, hastalık bilgileri) verilmiştir. Verilerin değerlendirilmesinde Student's t testi, ki-kare testi ve lojistik regresyon analizi kullanılmıştır.

Bulgular: Hasta grubu ile sağlıklı kontrol grubu arasında annenin hamileliğinde ilaç kullanması, ateşli hastalık geçirmesi, ruhsal veya fiziksel travma geçirmesi, hastanın hastanede doğması, uzamış doğum eylemi, çocuklukta gelişme, akrabalarda şizofreni öyküsü, okul öyküsü açısından anlamlı fark bulunmuştur. Şizofreni alt tipleri arasında eğitim düzeyi, doğum sırası ve okul öyküsü açısından anlamlı fark bulunmuştur.

Sonuç: Şizofreninin potansiyel risk faktörlerinin ve risk altındaki kişilerin belirlenmesi toplum sağlığı, sağlık giderleri, bireylerin ve toplumun şizofreniye bağlı olarak yaşadıkları olumsuz etkilerden korunmaları gibi bireysel ve toplumsal önemli yararlar sağlayacaktır.
Potential Risk Factors for Schizophrenia
Objective: Schizophrenia is a serious mental illness that affects the individual in various ways. Many risk factors have been suggested in the emergence of the illness. The aim of this study is to identify the potential risk factors for schizophrenia considering the characteristics of patients.

Methods: The study included 164 patients diagnosed with schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnostic criteria and a control group consisting of a matching number of healthy people. The subjects were given questionnaire forms on potential risk factors (prenatal and postnatal, sociodemographic, illness-related information). Student's t-test, chi-square test and logistic regression analysis were used to evaluate the data.

Results: Significant differences were identified between the patient group and healthy control group in terms of: for the mother- use of medication , history of inflammatory disease, or a psychical or physical trauma during pregnancy; -for the patient- being born in hospital, prolonged delivery, growth during childhood, relatives with a history of schizophrenia, and school history. Among the subtypes of schizophrenia, significant differences were identified in terms of educational level, birth rank and school history.

Conclusion: Identification of the potential risk factors for schizophrenia and of subjects at risk will provide important individual and social advantages, such as social health, health expenses and protection of individuals and society from the adverse effects of schizophrenia.

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