Amaç: Triptofan hidroksilaz (TPH 1) gen polimorfizminin bazı psikiyatrik bozukluklarla ilişkili olduğunun iddia edilmesi ve serotoninin üretiminde önemli bir rolü olan TPH 1 geninin beyne ve beyindeki nörotransmitter monoaminlere etkisi ve ikiuçlu hastalarda BOS serotonin düzeyi ile ilgili çalışmalar göz önüne alarak, Türk ikiuçlu hastalarda ve sağlıklı kontrol örneklerinde daha önce çalışılmamış bulunan TPH 1 geni 218 A>C (rs1800532) polimorfizmini; A/A, A/C ve C/C genotiplerinin sıklık ve dağılımını araştırmayı amaçladık.

Yöntemler: Gaziantep Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalı Duygudurum Bozuklukları Birimi'ne tedavi amacıyla başvuran hastalardan ve DSM-IV tanı ölçütlerine göre ikiuçlu bozukluk tanısı alan toplam 116 erişkin hasta ile çalışmanın yapıldığı Gaziantep Üniversitesi Tıp Fakültesi hastanesi çalışanlarından psikiyatrik açıdan sağlıklı olan gönüllüler arasından 150 kişi kontrol grubu olarak alınmıştır.

Bulgular: Kadın hastalarda A/A genotipi kadın kontrol vakalarına göre daha yüksek oranda görüldü. Hasta ve kontrol grubu arasında yaş ve cinsiyet dağılımı bakımından anlamlı farklılık bulunamadı. Hasta ve kontrol gruplarında A/A, A/C ve C/C genotipleri benzer oranlarda dağılmaktaydı.

Sonuç: TPH 1 geni 218 A>C polimorfizmi dağılımının hasta olan ve olmayan kadınlar arasında anlamlı farklılık ortaya çıkmıştır. Bu bulgu ikiuçlu bozukluğun erkek ve kadınlarda farklı seyretmesinin olası nedenlerinden biri olarak yorumlanabilir.
Methods: One hundred and sixteen adult patients who applied to the Mood Disorders Unit of Psychiatry Department, Medical School of Gaziantep University, and diagnosed with bipolar disorder (BD) according to DSM-IV diagnostic criteria were included in the study. One hundred and fifty healthy volunteers, a hospital staff at Gaziantep University, were involved as the control group.

Results: In female patients, the frequency of A/A genotype was found to be higher than in the females in the control group. No significant difference was detected between patient and control groups in terms of age and gender distribution. The distribution of A/A, A/C and C/C genotypes were similar in patient and control groups.

Conclusion: The distribution of TPH1 gene 218 A>C polymorphism was found to be significantly different between female patients and females in the control group. This result can be explicated as being one of the possible reasons for different course of bipolar disorder in male and female patients.

Objective: Considering the suggested association of tryptophan hydroxylase gene 1 (TPH1) polymorphism with some psychiatric disorders and studies concerning serotonin's effect on TPH 1 gene, brain and the neurotransmitter monoamines, as well as the studies performed on the serotonin levels in cerebrospinal fluid of bipolar patients, we aimed to investigate the frequencies and distribution of TPH 1 gene 218 A>C (rs1800532) polymorphism; A/A, A/C and C/C genotypes in bipolar patients and healthy control subjects for the first time in Turkish population (1-2).

Methods: One hundred and sixteen adult patients who applied to the Mood Disorders Unit of Psychiatry Department, Medical School of Gaziantep University, and diagnosed with bipolar disorder (BD) according to DSM-IV diagnostic criteria were included in the study. One hundred and fifty healthy volunteers, a hospital staff at Gaziantep University, were involved as the control group.

Results: In female patients, the frequency of A/A genotype was found to be higher than in the females in the control group. No significant difference was detected between patient and control groups in terms of age and gender distribution. The distribution of A/A, A/C and C/C genotypes were similar in patient and control groups.

Conclusion: The distribution of TPH1 gene 218 A>C polymorphism was found to be significantly different between female patients and females in the control group. This result can be explicated as being one of the possible reasons for different course of bipolar disorder in male and female patients.