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Yıl:2010; Cilt: 3; Sayı: 2>> Özet
Türkiye Klinikleri Psikiyatri Özel Dergisi; 2010;3(2):62-66
Şizofreni Tedavisinde Antipsikotikler Ve Farmakoekonomi
B Özdemir, A Algül, Ç Çelik, A Ateş
GATA Psikiyatri ABD, Ankara
Şizofreni maliyeti çok yüksek olan bir hastalıktır. Tedavinin maliyeti bireyler arasında farklı olabildiği gibi, aynı bireyin tedavisinde hastalığın durumuna göre ilaç değişimi, doz değişimi, yeni ilaçların eklenmesi, acil servislere başvuru ve rehabilitasyon hizmetleri gibi değişik gereksinimlere uygun olarak maliyetler değişebilmektedir. Antipsikotikler şizofreni tedavisinin temelini oluşturmaktadır. Şizofrenide farmakoekonomik analizler ilaçların maliyeti, etkinliği, yararlılığı ve tedaviden sosyal yararlanım düzeyi üzerinden yapılmaktadır. Tipik ve atipik antipsikotik ilaçlar arasında ilaç alım bedelleri bakımından ciddi farklar vardır. Bu güne kadar yapılan çalışmaların çoğunluğu atipik antipsikotiklerin farmakoekonomik değerinin tipik antipsikotiklerden daha yüksek olduğunu göstermektedir. Bununla birlikte atipik antipsikotiklerin yüksek tedavi maliyetlerinin istenmeyen yan etkiler açısından daha kolay tolere edilmeleri, negatif ve depresif belirtiler üzerindeki etkinlikleri, hastaneye yatış oranlarını düşürmeleri ve yaşam kalitesini arttırmaları nedeniyle uzun dönemde makul düzeylere gerilediği belirtilmektedir. Ülkemizde ise bu alanda yapılan çalışmalar yeterli değildir. Dolayısıyla ülkemizde bu gün şizofreni tedavisi için farmakoekonomik yönden kesin bir tanımlama yapmak mümkün değildir. Şüphesiz ilaç sektörü günümüzde ülkelerin ekonomik olanaklarını ciddi şekilde etkilemektedir. Bu açıdan ülkemizde farmakoekonomik çalışmaların daha sık yapılması önemli görünmektedir.
Pharmacoeconomics Of The Antipsychotics For The Treatment Of Schizophrenia
Schizophrenia is a disease that has too much cost. Treatment costs may vary across individuals or it may change by time at the same person throughout treatment. Costs can change according to necessities such as drug switching, dose changing, combination of new drugs, admission to emergency or rehabilitation services. Antipsychotics are the main components of schizophrenia treatment. Pharmacoeconomic analyses at schizophrenia are made upon cost, effectiveness, usefulness of drug and the level of social efficacy. Regarding to drug intake costs, significant differences arise between typical and atypical antipsychotics. Most of the studies conducted today have shown that pharmacoeconomic values of atypical antipsychotics are higher than typical antipsychotics. High cost of atypical antipsychotics draws back to acceptable levels at long periods by their tolerability about side effects, their effectiveness on negative and depressive symptoms, decreasing hospitalization rates and increasing the quality of life. In our country, studies on this area are currently insufficient, so it is not possible to make a clear definition on pharmacoeconomic aspects of schizophrenia treatment. Surely, drug industry is affecting economic states of all countries seriously. From this point of view, making more studies on pharmacoeconomy should be important for our country.

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