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Yıl:2009; Cilt: 19; Sayı: 4>> Özet
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Klinik Psikofarmakoloji Bülteni; 2009;19(4):423-427
Klozapine yanıt veren asperger bozukluğu ve şizofreni eştanılı bir ergen olgu
A Bilgiç, BG Kılıç, EZ Kılıç
Ankara Eğitim ve Araştırma Hastanesi, Çocuk ve Ergen Psikiyatrisi
Asperger bozukluğu (AB) olgularında ve ailelerinde şizofreni ve diğer psikotik bozuklukların sıklığının yüksek olduğu düşünülmektedir. Bununla birlikte, AB’de görülen şizofreninin tedavisi ile ilgili bilgiler sınırlıdır. Bu makalede AB ve şizofreni eştanısı bulunan 15 yaşında bir ergen olgu sunulmuştur. Olgunun psikotik belirtileri sırasıyla, ketiapin, risperidon ve pimozid tedavilerine yanıt vermemiş, bunun üzerine başlanan klozapin ile tedavinin dördüncü ayı sonrasında iyileşme görülmeye başlanmıştır. Sunulan olgu bağlamında AB ve şizofreni eştanısı ve bu olgularda şizofreni gelişiminde ailesel yüklülüğün olası etkileri tartışılmıştır.
An adolescent case with Asperger disorder and comorbid schizophrenia responded to clozapine
It is suggested that frequency of schizophrenia and other psychotic disorders is high in cases with Asperger disorder (AD) and in their families. On the other hand, information regarding management of schizophrenia in cases with AD is limited. In this paper, a 15- [year]-old adolescent case with AD and comorbid schizophrenia, is reported. His psychotic symptoms did not respond to quetiapine, risperidone, and pimozide, respectively. Then, clozapine was commenced and the patient began to improve at the fourth [month] of the clozapine treatment. In context of the reported case, challenges during the treatment process in cases with AD plus schizophrenia and possible familial insuences on schizophrenia development in such cases are discussed.

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