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Yıl:2009; Cilt: 19; Sayı: 3>> Özet
TAM METİN
Klinik Psikofarmakoloji Bülteni; 2009;19(3):297-303
Antipsikotiklere bağlı kilo alımının farmakogenetiği
C Şengül, H Herken
Pamukkale Üniversitesi Psikiyatri AD, Denizli-Türkiye
Psikiyatri hastalarında antipsikotik ilaçların kullanımına bağlı olarak ortaya çıkan belirgin kilo alımı ve metabolik sendrom, başta diyabet olmak üzere ciddi sağlık sorunlarına neden olmaktadır. İlaçlara bağlı kilo alımı herkeste benzer nitelikte olmayıp, kullanılan ilaca ve bireye bağlı olarak değişmekle birlikte, en sık olarak atipik antipsikotik kullananlarda gözlenmektedir. Başta genetik çalışmalar olmak üzere hangi hastanın ne oranda kilo alacağının öngörülebilmesine yönelik çalışmalar devam etmektedir. Bu gözden geçirme yazısında şimdiye kadar konu ile ilgili yapılan çalışmalar gözden geçirilmiş olup, kilo alımının genetiğinin ortaya konulmasına yönelik yapılacak olan genetik çalışmalara yol göstermek amaçlanmıştır.
Pharmacogenetics of antipsychotic-induced weight gain
Antipsychotic-induced noticeable weight gain and metabolic
syndrome cause serious health problems in psychiatric patients
with the foremost of diabetes. The nature of medicationinduced
weight gain is not the same for everyone; besides
varying with the medication and person, most frequently it is
observed in people using atypical antipsychotics. Mostly
Foremost genetic, but also other studies researching to predict
what rate of weight gain in which patients have been going on.
With the aim of guiding future genetic studies exploring the
genetics of weight gain the previous studies conducted on this
topic were reviewed in this study.

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