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Yıl:2009; Cilt: 19; Sayı: 3>> Özet
TAM METİN
Klinik Psikofarmakoloji Bülteni; 2009;19(3):220-225
Okul eğitimin süresinin erişkin beyni üzerine olan etkisi: Bir voksel tabanlı morfometri - DARTEL çalışması
AS Gönül, O Demirel, Ö Kitis, Ç Eker, ÖD Eker, E Ozan
Ege University, School of Medicine Department of Psychiatry, İzmir, Turkey
Amaç: Son dönemde yapılan çalışmalar çevresel uyaranların sürekli verilmesinin beyinde yapısal değişikleri tetikleyebileceğini göstermiştir. Okul eğitimi sırasında, insan beyni sadece yeni bilgiler ile karşılaşmamakta, eski bilgilerini de çağırarak yenileri ile birleştirmektedir. Biz bu çalışmada, yoğun öğrenme sürecinin yaşandığı okulda geçirilen sürenin beyin üzerindeki etkisini voksel tabanlı morfometri (VBTM) ' DARTEL yöntemini kullanarak araştırmayı amaçladık. Yöntem: Bu çalışmaya 47 sağlıklı erişkin dahil edildi. SCID-NP ile taranan hastaların daha sonra 1.5 T gücündeki Siemens Manyetik Rezonans Görüntüleme cihazı ile beyin görüntüleri alındı. T1 ağırlıklı görüntüler SPM 5'te (Statistical Parametric Mapping software) VBTM protokolü kullanılarak değerlendirildi. Bulgular: VBTM değerlendirmesi sonucunda sağ ön hipokampus hacminin eğitim ile korele olduğu tespit edildi. Bilateral oksipital loblarda (BA 18) ve sağ serebullum da eğitim süresinin artmasına paralel gri madde artışı tespit edildi. Sağ parietal korteks (BA 7) ve sağ orta frontal kortekste (BA 8) ise gri madde miktarı eğitim süresi ile negatif korelasyon göstermekteydi. Sonuçlar: Bu çalışmanın sonuçları beyinin yeni uyaranın tespiti, semantik ve uzay bellek ve görsel sistemler ile ilgili alanlardaki gri madde hacmi ile okulda geçirilen süre arasında ilişki olduğunu göstermiştir. Bu ilişki ilgili alanlarının yoğun uyarımı ile ilişkili olabilir.
The effects of the duration of formal education on adult brain: a voxel-based morphometry - (diffeomorphic anatomical registration using exponentiated lie algebra) DARTEL Study
Objective: Recent studies neuroimaging showed that
continues environmental stimuli can induce structural
changes in the brain. Compared to later life, during formal
education in school and university; human brain is not only
continuously stimulated with new information but also
retrieves the already learned information and extends it
with the new one. In this study, we explored the effects of
this extensive learning process on brain structure by using
voxel-based morphometry (VBM) ?DARTEL method.
Method: Forty-seven healthy adults were included in this
study. After screened carefully by SCID-NP, all subjects were
scanned by Siemens 1.5T Magnetic Resonance Imaging
machine. T1 weighted images were analyzed by SPM 5
(Statistical Parametric Mapping software) via VBM protocol.
Results: Our VBM results showed that the right anterior
hippocampus gray matter volume was correlated with the
duration of formal education. We also observed that
education showed positive correlations with Brodmann
(BA) 18 in the occipital lobes and with the right cerebellum.
However, the right parietal cortex (BA 7) and the right
middle frontal cortex (BA 8) showed negative correlations
with education.
Conclusion: Our study showed that there is an association
between the duration of formal education and the gray
matter volume of brain regions related to the detection of
novel stimuli, semantic and spatial memory and visual
system which might be related to extensive learning
process during formal education [year]s.

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