Dergi Ara >>
Yıl:2009; Cilt: 10; Sayı: Ek 1>> Özet
Anadolu Psikiyatri Dergisi; 2009;10(Ek 1):74-75
Sekonder hiperparatiroidizme bağlı katatoni: Bir olgu sunumu
OB Eğilmez, H Alkan, DÖ Yalçın, AF Kaya, MÇ Aydemir
Numune Eğitim ve Araştırma Hastanesi, Ankara
Katatoni, stupor, künt duygulanım, aşırı nega-tivizm, mutizm, ekolali, ekopraksi, rijidite ve postural anormalliklerin eşlik edebildiği klinik bir sendrom olarak tanımlanmıştır. DSM-IV'te katatoni, katatonik şizofreni, katatonik özellikli majör depresyon, katatonik özellikli manik ve mikst epizot, genel tıbbi bir duruma bağlı katatonik bozukluk başlıkları altında sınıflandırılmıştır. Genel tıbbi duruma bağlı katatonik bozukluğa neden olan hiperparatiroidizm, paratiroid bezlerinin normalden fazla parathormon salgılaması sonucunda ortaya çıkmaktadır.

Primer hiperparatiroidizm paratiroid bezlerine ait patolojiler sonucunda ortaya çıkarken, sekonder hiperparatiroidizm kronik böbrek yetmezliği, yetersiz kalsiyum alımı ve D vitamini eksikliğine ikincil olarak paratiroid bezlerinin fazla çalışması ile ortaya çıkar.Sekonder hiperparatiroidizmde serumda PTH düzeyleri yüksek; kalsiyum, fosfor ve vitamin D düzeyi ise etiyolojiye bağlı olarak normal, yüksek veya düşük olarak saptanmaktadır.Çalışmalarda hiperparatiroidizmi olanlarda psikiyatrik belirtilerin görülme sıklığı 1-50% arasında bulunmuştur. Bu belirtilerden en yaygın olanları genel apati ve hafif bilişsel bozukluğun eşlik ettiği depresif belirtilerdir. Hiperparatiroidizme bağlı olarak depresyon, anksiyete bozuklukları ve paranoid psikoz görülebilmektedir.

Kliniğimize oral alım kısıtlılığı, rijidite, balmumu esnekliği ve mutizm tablosu ile başvuran ve yapılan tetkikler sonucunda D vitamini eksikliğine bağlı sekonder hiperparatiroidi saptanan bir hastayı sunacağız. Bu olgu üzerinden kalsiyum ve vitamin D metabolizmasının psikiyatrik bozukluklar açısından önemi tartışılacaktır.
Catatonia depending on secondary hyperparathyroidism: A case report
Catatonia has been defined as a clinical syn-drome, to which state of stupor, obtuse affect-tion, excessive negativism, mutism, echolalia, echopraxia, rigidity and postural abnormalities are able to accompany. In DSM-IV, catatonia has been classified under the titles of the cata-tonic schizophrenia, catatonic-featured major depression, catatonic-featured manic and mixed episode and catatonic disorder depending on general medical condition. Hyperparathyroidism, which causes to a catatonic disorder depending on the general medical condition, arises as result of parathyroid glands? excretion of higher than normal levels of parathormone.

While primary hyperparathyroidism occurs be-cause of pathologies that belong to parathyroid glands, secondary hyperparathyroidism arises because of the parathyroid glands? excessive action secondarily depending on chronic renal impairment, insufficient calcium intake and vita-min D deficiency. In secondary hyperparathyroi-dism, PTH levels are determined as high, while calcium, phosphor and vitamin D levels are as normal, high or low, depending on etiology.Frequency of the psychiatric symptoms in people having hyperparathyroidism has been found between 1-50% in studies. Most common of these symptoms are depressive symptoms, to which general apathy and mild cognitive disor-ders accompany. Depression, anxiety disorders and paranoid psychosis can be seen depending on the hyperparathyroidism.

We will present a patient, who has applied to our clinic with oral intake disability, rigidity, cerea flexibilities and mutism, and diagnosed for a secondary hyperparathyroidism depending on vitamin D deficiency because of examinations. This case will be used to discuss the importance of the calcium and vitamin D metabolism from the point of the psychiatric disorders.

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