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Yıl:2009; Cilt: 46; Sayı: 1>> Özet
TAM METİN
Nöropsikiyatri Arşivi; 2009;46(1):19-23
Anksiyete Bozukluklarında Antikonvülzanların Etkinliği ve Bir Tedavi Seçeneği Olarak Yeri
R Tükel
İstanbul Üniversitesi İstanbul Tıp Fakültesi, Psikiyatri Anabilim Dalı, İstanbul, Türkiye
Anksiyete bozukluklarında tedavi seçenekleri, ilaç tedavileri ve bilişsel-davranışçı tedavileri içerir. Çoğu anksiyete bozukluğu için ilaç tedavilerinin ilk basamağını, seçici serotonin gerialım inhibitörleri ve serotonin noradrenalin gerialım inhibitörleri oluşturmaktadır. Çeşitli çalışmalarda, karbamazepin, valproat, lamotrijin, topiramat, gabapentin ve pregabalini içeren antikonvülzanların anksiyete bozukluklarında etkili olduğu gösterilmiştir Anksiyete bozukluklarında antikonvülzanlar için en güçlü kanıtların; yaygın anksiyete bozukluğu için pregabalin ve valproik asit, sosyal anksiyete bozukluğu için pregabalin ve gabapentin, travma sonrası stres bozukluğu için lamotrijin ile sağlandığı görülmektedir. Antikonvülzanların, geleneksel tedavilere dirençli hastalarda alternatif bir tedavi seçeneği olarak etkinliğini belirlemek üzere daha ileri çalışmalara ihtiyaç vardır.
The Efficacy and Role of Anticonvulsants as a Treatment Option in Anxiety Disorders
Treatment options for anxiety disorders include pharmacotherapy and cognitive-behavioral therapy. Selective serotonin reuptake inhibitors and serotonin noradrenalin reuptake inhibitors are the first-line pharmacological treatment approach for most of the anxiety disorders. The efficacy of anticonvulsants in anxiety disorders, including carbamazepine, lamotrigine, topiramate and gabapentin has been shown in some clinical studies. The strongest evidence has been provided for pregabalin and valproic acid in generalized anxiety disorder, pregabalin and gabapentin in social anxiety disorder, and lamotrigine in posttraumatic stress disorder. Further research is needed to determine the efficacy of anticonvulsants as an alternative therapeutic option for the patients resistant to conventional treatment.

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