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Yıl:2004; Cilt: 11; Sayı: 1>> Özet
TAM METİN
Çocuk ve Gençlik Ruh Sağlığı Dergisi; 2004;11(1):11-15
Dikkat Eksikliği Hiperaktivite Bozukluğunda Kalsiyum Bağımlı Fosfolipaz A2 Düzeyleri
B Dilaver, Ö Yorbık, A Olgun, Ş Akman, T Söhmen
Amaç: Çeşitli hayvan ve insan çalışmalarında Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) belirtileri ile esansiyel yağ asiti eksikliği belirtileri arasında benzerlikler olduğu bildirilmiştir. Bu nedenle, fosfolipid metabolizması DEHB etyolojisinde ve klinik tablosunda rol oynayabilir. Bu çalışmanın amacı DEHB olan erkek çocukların sekretuar kalsiyum bağımlı fosfolipaz A2 (sPLA2) düzeylerini sağlıklı kontroller ile karşılaştırmaktır. Yöntem: DEHB olan 39 erkek çocuğun ve yaş, cinsiyet, ırk, sosyoekonomik düzey açısından DEHB grubuna benzer olan 18 normal kontrolün serum sPLA2 düzeyleri karşılaştırılmıştır. Bulgular: Serum sPLA2 düzeyleri bakımından DEHB ve sağlıklı kontrol grubu arasında istatistiksel olarak önemli bir farklılık saptanmamıştır (p>.05). Tartışma: Bu çalışma, DEHB'nin PLA2 disfonksiyonu ile birlikte olmadığını düşündürmüştür.
Calcium-Dependent Phospholipase A2 Levels in Attention Deficit Hyperactivity Disorder
Objective: Several previous studies indicated that some physical symptoms reported in Attention Deficit Hyperactivity Disorder (ADHD) are similar to symptoms in animals and humans deprived of essential fatty acids. Thus, phospholipid metabolism may play a role in the pathogenesis and clinical presentation of ADHD. Method: The serum activity of secretory calcium-dependent A2 (sPLA2) in 39 boys with ADHD was compared with 18 age, sex and socioeconomic status matched normal controls. Results: There was no statistically significant difference between the mean sPLA2 activity levels of boys with ADHD and normal controls. Conclusion: This study suggested that ADHD may not associated with dysfunction of PLA2.

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