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Yıl:2008; Cilt: 18; Sayı: 4>> Özet
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Klinik Psikofarmakoloji Bülteni; 2008;18(4):306-308
Fluvoksamine bağlı kütanöz lökositoklastik vaskülit
İ Eren, İ Çivi, M Şahin
Süleyman Demirel Üniversitesi, Tıp Fakültesi Psikiyatri AD, Isparta
Fluvoksamin psikiyatri pratiğinde depresyon, panik bozukluğu, obsesif kompulsif bozukluk ve yeme bozukluğu tedavisinde yaygın olarak kullanılmaktadır. Lökositoklastik vaskülit postkapiller venlerde immün kompleks depolanması ile karakterize ciddi ilaç reaksiyonudur. Genellikle sistemik tutulumla birlikte ya da sistemik tutulum olmadan alt ekstremitelerde purpura şeklinde görülür. Biz obsesif kompulsif bozukluğu olan bir hastada fluvoksamine bağlı gelişen lökositoklastik vaskülit gelişimini sunmaktayız. Antidepresanlar nadiren lökositoklastik vaskülite neden olmaktadır ve bilgilerimize göre daha önce fluvoksamin ile bildirilmemiştir
Cutaneous leucocytoclastic vasculitis associated with fluvoxamine
Fluvoxamine is widely used in psychiatry practice in the treatment of depression, panic disorder, obsessive-compulsive disorder, and eating disorders. Leucocytoclastic vasculitis is a serious drug reaction that is characterized by immune complex deposition in the postcapillary venules. It usually presents as purpura on the lower extremities with or without systemic involvement. Here, we report fluvoxamine induced leucocytoclastic vasculitis in a patient with obsessive compulsive disorder. Antidepressants have rarely been associated with leucocytoclastic vasculitis, and to the best of our knowledge vasculitis of any type has not previously been reported in association with fluvoxamine

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