Dergi Ara >>
Yıl:2008; Cilt: 18; Sayı: 4>> Özet
TAM METİN
Klinik Psikofarmakoloji Bülteni; 2008;18(4):245-250
Antipsikotikler, antidepresanlar: Meta-analiz güvenirliği
M Çetin
GATA Haydarpaşa Eğitim Hastanesi, İstanbul, Türkiye
Son zamanlarda bilimsel araştırmaların meta-analizleri çeşitli yayın organlarında yanlış anlaşılmalara yol açacak şekilde sunulmuştur. Bu yazıda bunlardan Kirsh ve arkadaşlarının antidepresan tedavilerin plaseboya göre orta derecede bir üstünlükleri olduğu ve yayınlanmamış verilerin dahil edilmesi ile antidepresan etkinliğin daha düşük olacağı sonucuna ulaşıldığı meta-analizi ile, Leucht ve arkadaşlarının şizofreni tedavisinde kullanılan ikinci kuşak antipsikotiklerin kafa kafaya karşılaştırılmalarının meta-analizinin yer aldığı güncel iki çalışma irdelenecektir.
Antidepressants, antipsychotics: Reliability of meta-analyses
Recently, some meta-analyses of published scientific research were were presented in a way that would lead misinterpretations and misunderstandings. In this article, Kirsh et al.’s meta-analysis entitled “Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration” and Leucht et al.’s meta-analysis entitled “A Meta-analysis of head-to-head comparisons of second-generation antipsychotics in the treatment of schizoprenia” were reviewed.

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