Dergi Ara >>
Yıl:2008; Cilt: 45; Sayı: Özel>> Özet
TAM METİN
Nöropsikiyatri Arşivi; 2008;45(Özel):1-5
Multipl Skleroz Tanısında Tarihsel Gelişim ve Son Durum
M Mutlu, GA Demir
İstanbul Üniv. İstanbul Tıp Fak. Nöroloji ABD, İstanbul
Multipl skleroz dünyada bir milyon kişiyi etkileyen bir hastalık olup, genç erişkinlerde nörolojik özürlülüğe yolaçan hastalıkların en sık sebebidir. Son yıllarda multipl skleroz'un tanı ve tedavisi ile ilgili bilgilerimizdeki gelişmelere rağmen, halen hastalığın nedeni, patogenezi ve mekanizması ile ilgili birfikir birliğine varılabilmiş değildir. Yeni veriler multipl skleroz'un inflamatuvar, nörodejeneratif bir hastalık olduğunu, hem adaptif, hem de kazanılmış immun sistemin bu hastalığın gelişmesinde ve sürmesinde önemli rolleri bulunduğunu göstermektedir.
Diagnosis of Multiple Sclerosis: Historical Evaluation and Current Status
Multiple sclerosis affects one million people in the worldwide and is leading cause of neurological disability in young adults. Despite recent advances in the diagnosis and treatment of multiple sclerosis, we still lack a consensus about the causes, pathogenesis and mechanism of disease progression. New evidence indicates that multiple sclerosis is an inflammatory neurodegenerative disorder in which both adaptive and innate immune system play important roles in initiation and maintenance of the disease.

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