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Yıl:2008; Cilt: 45; Sayı: 1>> Özet
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Nöropsikiyatri Arşivi; 2008;45(1):14-18
Demanslı Hastalarda Kognitif Bozulma ve Nöropsikiyatrik Etkilenmenin Günlük Yaşam İşlevleri Üzerine Etkisi
A Özge, OÖ Yalın, H Kaleağası, S Bayram, Ç Kudiaki
Mersin Ü. Tıp Fak. Nöroloji ABD, Mersin
Amaç: Demanslı hastalarda kognitif bozulmaya eşlik eden davranışsal bulgular sıklıkla bildirilmekle birlikte demans alt tiplerine göre kognitif ve nöropsikiyatrik etkilenmenin günlük yaşam işlevleri üzerine etkisi hakkında çelişkili bilgiler mevcuttur. Bu çalışmada hafif kognitif bozukluk (HKB), Alzheimer hastalığı (AH) ve vasküler demans (VD) tanısı alan hastalarda kognitif ve nöropsikiyatrik etkilenmenin günlük yaşam işlevleri üzerine etkisi değerlendirildi.

Yöntem: Çalışmaya 18 HKB, 40 AH, 17 VD hastası ve 23 sağlıklı kontrolden oluşan toplam 95 birey dahil edildi. Tüm hastalara TAÇ grubu veri tabanında yer alan nöropsikiyatrik değerlendirme ve işlevsellik testleri uygulanarak DSM-IV ve uluslararası çalışma grupları kriterlerine uygun tanı konuldu.

Bulgular: Cinsiyet ve eğitim düzeyi açısından eşleştirilmiş olan örneklemde AH grubunda daha belirgin olmak üzere genel olarak kognitif bozulma (MMSE skorları) ve toplam NPI skorlarının (sıklık, şiddet, sıkıntı alt grupları için de geçerli olmak üzere) Blessed işlevsellik ölçeği ve enstrumental günlük yaşam işlevleri ölçeği puanları üzerine anlamlı ölçüde olumsuz etki gösterdiği ve her üç grup ölçek puanları arasında anlamlı korelasyon olduğu saptandı.

Sonuç: Bulgularımız unutkanlık yakınması ile başvuran hastaların değerlendirilmesinde kognitif değerlendirmenin mutlaka nöropsikiyatrik ve işlevsellik değerlendirmesi ile tamamlanması gereğini destekledi.
The Effect of Cognitive Decline and Neuropsychiatric Symptoms on Activities of Daily Living in the Dementia Patients
Objective: Neuropsychiatric symptoms of people with dementia are frequently reported, but knowledge about the effects of cognitive and neuropsychiatric symptoms on daily activities in various dementia subtypes is conflicting. In this study, we investigated the influence of cognitive and neuropsychiatric symptoms on daily activities in mild cognitive impairment (MCI), Alzheimer Disease (AD) and Vascular Dementia (VD) patients.

Method: Eighteen MCI, 40 AD, 17 VD patients and 23 healthy volunteers, making a total of 98 persons, were admitted to the study. All patients were evaluated with cognitive, neuropsychiatric and functionality scales found in the Dokuz Eylül dementia database registry, and patients were diagnosed according to DSM-IV and international study group criteria.

Results: All groups were matched according to sex and education. We showed NPI (neuropsychiatric inventory for all frequency, severity, caregiver distress scores) and cognitive decline (MMSE scores) as being more prominent among AD; it has a significantly negative effect on Blessed functionality scale and instrumental daily living scale, and results were correlated with each other in all three groups.

Discussion: Our results suggest that patients who have complaints of forgetfulness should be given a cognitive evaluation in addition to neuropsychiatric and functional scales determination.

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