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Yıl:2007; Cilt: 9; Sayı: 2>> Özet
Türkiye'de Psikiyatri; 2007;9(2):108-116
Yeme Bozukluklarının Nörobiyolojisi
E Güney, AÇ Kuruoğlu
Gazi Ü. Tıp Fak. Çocuk Psikiyatri ABD, Ankara
Yeme bozuklukları psikolojik, sosyolojik ve biyolojik faktörlerin etkileşimini içeren karmaşık sendromlar olup
DSM-IV'de anoreksiya nervoza, bulimiya nervoza ve başka türlü adlandırılamayan yeme bozuklukları şeklinde
sınıflandırılmaktadır. Modern toplumların zayıf görünüm ve beden egzersizlerine verdiği önem gibi
sosyolojik etkenler ve ergenlik dönemindeki bağımsızlık beklentisi ile sosyal ve cinsel işlevsellikteki artmaya
karşı tepki şeklindeki psikolojik etkenler yanında, son zamanlarda yeme bozukluklarının gelişimine katkıda
bulunan biyolojik faktörler etyolojide önem kazanmaya başlamıştır. Genetik analizlerin, nörogörüntüleme
tekniklerinin ve enerji dengesini etkileyen nöropeptidlerin tanımlanmasındaki artış ile yeme bozukluklarının
nörobiyolojisi ile ilgili araştırmalarda canlanma görülmektedir. Bu makalede de etyolojide giderek önemli
bir yer tutmaya başlayan bu nörobiyolojik çalışmaların gözden geçirilmesi amaçlanmıştır.
Neurobiology of eating disorders
Eating disorders are complex syndromes composed of interacting psychological, sociological and biological factors, classified in DSM-IV
as anorexia nervosa, bulimia nervosa and eating disorders not otherwise specified. Recently, more weight has been given to the biological
issues that contribute to the development of eating disorders, along with the sociological aspects such as the importance ascribed to the
slim body shape and physical exercise in modern societies and the psychological factors taking the form of a reaction against expectations of
independence, as well as an increased social and sexual functioning in adolescence. Research on the neurobiology of the eating disorders
gained momentum as genetic analyses, neuroimaging techniques and the description of the specific neuropeptides influencing the energy
balance have become more widespread and well-known. In this report, these neurobiological studies, which assume central importance in
the etiology of eating disorders will be reviewed.

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