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Yıl:2007; Cilt: 44; Sayı: 3>> Özet
TAM METİN
Nöropsikiyatri Arşivi; 2007;44(3):91-94
Epilepsi ve Parkinsonizm Arasındaki İlişki
Y Kaplan
Gaziosmanpaşa Üniversitesi Tıp Fakültesi Nöroloji Anabilim Dalı, Tokat, Türkiye
Amaç: Bu çalışmada parkinsonizmle birlikte epilepsisi olan hastalarda nöbetle­rin tipi, özgeçmiş özellikleri, elektroensefalogram (EEG), magnetic resonance imaging (MRI) ve anti-epileptik tedaviler değerlendirildi. Yöntem: 2002 ile 2006 yılları arasında nöroloji polikliniğinde parkinsonizm tanısı ile izlenen 127 hasta gözden geçirildi. Parkinsonizmle birlikte epilepsisi olan, MRI'lan normal ve diğer potansiyel epileptojenik patolojilerin olmadığı 6 hasta çalışma için uygun bulundu.
Sonuçlar: 6 hastanın 5'i kadın, Ti erkekti. 3 hastada jeneralize tonik klonik nö­betler, 2 hastada parsiyel başlangıçtı sekonder jeneralize ve 1 hastada komp­leks parsiyel nöbetler vardı. Özgeçmiş sorgulamasında 4 hastada kafa travma­sı öyküsü alınıyordu. Hastalar karbamazepin ve/veya valproik asit tedavisi al­mışlardı.
Tartışma: Bu veriler bize, kafa travması öyküsü, sık geçirilen epileptik nöbetler veya kullanılan anti-epileptik ilaçların yan etkisi gibi bir çok faktörün tek başla­rına veya birlikte birbirinden farklı bu iki hastalığın ilişkisinde ortak payda olabi­leceklerini düşündürtmüştür. Ayrıca epilepsi ile parkinsonizmin birlikte görüldü­ğü klinik tabloların gerçekten ilişkili veya tamamıyle rastlantısal bir durum olup olmadığının daha fazla sayıda hastayı içeren çalışmalarla değerlendirilmesi gerekir.
The Relationship Between Epilepsy and Parkinsonism
Objective: This study evaluated the type of seizures, electroencephalography (EEG), magnetic resonance imaging (MRI), past medical history, and antiepilep-tic therapy in patients with both epilepsy and parkinsonism. Method: We reviewed all patients with parkinsonism who visited our outpatient clinic between 2002 and 2006. We identified 127 patients with parkinsonism. Out of 127 patients, 6 patients (5 female, 1 male) had both epilepsy and parkinso­nism. In all of these patients, MRI was normal. There was no evidence of other potentially epileptogenic pathologies.
Results: Three patients had generalized tonic-clonic seizures; two patients had partial seizures with secondary generalization; and one patient had complex partial seizures. Four patients had a history of head trauma. All the patients with seizure activity were treated with carbamazepine and/or valproate. Discussion: The results led us to postulate that head trauma, frequent seizures, or the adverse effects of antiepileptic drugs might be the only or common par­ticipant to these two completely different diseases. Besides, clinic conditions which epilepsy and parkinsonism are seen together should be further tested by more patients in orderto determine whetherthe conditions are really related or completely co-occur by chance. (

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