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Yıl:2006; Cilt: 9; Sayı: 3>> Özet
TAM METİN
Klinik Psikiyatri Dergisi; 2006;9(3):131-137
Klinik ve Subklinik Hipotiroidide Psikiyatrik Belirti Düzeyi ve Psikiyatrik Belirtilerin Tiroid Hormon Düzeyleri İle İlişkisi
İ Eren, E Cüre, İÇ İnanlı, A Kutlucan, BK Köroğlu, MN Tamer
Süleyman Demirel Ü. Tıp Fak. Psikiyatri ABD, Isparta
Amaç: Hipotiroidide psikiyatrik belirtilerin sık görüldüğü bildirilmektedir. Klinik ve subklinik hipotiroidide psikiyatrik belirtiler ve depresyon düzeylerini ve bunların tiroid hormon düzeyleri ile ilişkisini araştırmayı amaçladık. Yöntem: Endokrinoloji polikliniğine başvuran 40 hipotiroidi hastası ile 40 subklinik hipotiroidi hastası, toplam 80 hasta ile 45 sağlıklı birey çalışmaya dahil edildi. Tüm bireylere Beck Depresyon Ölçeği (BDÖ), Beck Anksiyete Ölçeği (BAÖ) ve Kısa Semptom Envanteri (KSE) uygulandı. Bulgular: Hipotiroidi olan grupta, somatizasyon, obsesif kompulsif bozukluk, anksiyete, fobik anksiyete, paranoid düşünce, psikotiklik, ek madde alt ölçek ve rahatsızlık ciddiyeti indeksi puanları kontrollerden anlamlı olarak yüksek bulundu. Subklinik hipotiroidisi olan grupta somatizasyon, obsesif kompulsif bozukluk, kişilerarası duyarlılık, hostilite, anksiyete, fobik anksiyete, psikotiklik, ek madde alt ölçek ve rahatsızlık ciddiyeti indeksi puanları kontrollerden anlamlı olarak yüksek bulundu. Serbest T3 ve TSH hormon düzeylerinin psikiyatrik belirti, depresyon ve anksiyete düzeyleri ile ilişkili olmadığı saptandı. Serbest T4 düzeyleri ise anksiyete alt ölçek ve BAÖ puanları ile pozitif korele idi. Sonuç: Hipotiroidi ve subklinik hipotiroidi hastalarında sağlıklı kontrollere göre psikiyatrik belirtilerin daha yüksek oranda görüldüğü ortaya konuldu. Ancak bu belirtiler ile tiroid hormon düzeyleri arasında yaygın bir korelasyon mevcut değildi.
Psychiatric Symptom Level in Clinical and Subclinical Hypothyroidism and Its Relation Between Thyroid Hormon Levels
Objectives: It is reported that psychiatric symptoms are frequently seen in hypothyroidism. We aimed to investigate psychiatric symptoms and depression levels in clinical and subclinical hypothyroidism and their relation to thyroid hormone levels. Method: Fourty patients with hypothyroidism and 40 patients with subclinical hypothyroidism who admitted to Endocrinology out patient clinic and 45 healthy indivudials were included into the study. All indivudials were administered Beck's depression inventory (BDI) and Beck's anxiety inventory (BAI) and Brief Symptom Inventory. Results: In hypothyroid group, the points of somatization, obsessive-compulsive disorder, anxiety disorder, phobic anxiety, paranoid idea, psychosis, additional item subscale, global severity index were significantly higher than control group. In the subclinical hypothyroid group, the points of somatization, obsessive-compulsive disorder, interpersonal sensitivity, hostility, anxiety, phobic anxiety, psychosis, additional item subscale and global severity index were significantly higher than control group. We found that free triiodothyronine and thyrotropin hormone levels were not related with psychiatric symptoms, depression and anxiety levels. Free thyroxine levels were positively correlated with anxiety subscale and BAI points. Conclusion: Psychiatric symptoms were seen more frequently in hypothyroid and subclinical hypothyroid patients compared with healthy control group. But these symptoms were not correlated extensively with thyroid hormone levels.

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