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Yıl:1997; Cilt: 2; Sayı: 1>> Özet
Ege Psikiyatri Sürekli Yayınları; 1997;2(1):105-112
Nöroendokrinimmünoloji
E Terzioğlu
Ege Ü. Tıp Fakültesi, İzmir
Nöroendokrin immünoloji hızlı büyüyen bir araştırma alanı olup bu konuda birçok araştırma yapılmakta ve bu yolla nörolojik ve psikiyatrik hastalıkların etyopatogenezleri araştırılmaya çalışılmaktadır. Yapılan çalışmalarda sitokinler, peptit hormonlar ve nörotransmitterlerin ve bunların reseptörlerinin beyin, endokrin ve immün sistem olmak üzere 3 temel sistemde de mevcut olduğu gösterilmiştir. Bu yolla immün ve nöroendokrin sistem arasında karşılıklı bir konuşma vardır. Beyin immün düzenleyici bir rol üstlenmekte, immün sistem ise bir duyu organı gibi görev yapabilmektedir. Primer ve sekonder lenfoid organlarda yer alan immün sistemin hücrelerinin hormonları ve nöropeptitleri, buna karşın endokrin bezlerinde immün sistemin ürünü olduğu bilinen çeşitli sitokinleri sentez edebildiği gösterilmiştir. Ayrıca bütün bu moleküller yani hormonlar ve sitokinler için gerekli reseptörler immün ve nöroendokrin sistem hücrelerinde ifade edilirler. Nöroendokrin ve immün sistem arası bu ilişkilerin daha iyi anlaşılması, hem fizyolojik olayların daha iyi anlaşılmasına hem de hastalıkların tedavisinde yeni ufuklar açılmasına yol açabilir.

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