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Yıl:2004; Cilt: 5; Sayı: 3>> Özet
TAM METİN
Bağımlılık Dergisi; 2004;5(3):133-138
Sigara bağımlılarında solunum havasında karbonmonoksit düzeyleri
A Türkcan, D Çakmak
Bakırkör Ruh ve Sinir Hast. Hastanesi, İstanbul
Amaç: Sigara içme durumunun belirlenmesinde birçok yöntem vardır. Solunumla verilen havada karbonmonoksit ölçümü geçerli ve uygulanması elverişli bir yöntemdir. Bu çalışmanın amacı sigara içenlerle içmeyenler arasında ayırım yapmada nefes karbonmonoksit konsantrasyonlarının kesim noktasını saptamaktır.

Yöntem: Elle taşınan bir cihaz (Micro CO) solunumla verilen havadaki karbonmonoksit konsantrasyonlarını ölçmekte kullanıldı. 31 sigara içicisinin ve 30 sigara içmeyen kişinin nefes karbonmonoksit düzeyleri ölçüldü.

Bulgular: Sigara içmeyenler grubunda karbonmonoksit konsantrasyonları 0-5 ppm (milyonda partikül), sigara içenler grubunda 5-70 ppm olarak saptandı. Sigara içenlerin ortalama karbonmonoksit konsantrasyonu 27.8 + 17.0 ppm, sigara içmeyenlerin 1.7 +1.0 ppm’ydi (p<0.01). Karbonmonoksit konsantrasyonları içilen sigara sayısıyla doğru orantılı biçimde artmaktaydı (p<0.01). Sigara içenlerle içmeyenlerin ayırımında karbonmonoksit düzeyi kesim noktası % 96.8 duyarlılık ve % 96.7 özgüllükle 5 ppm olarak saptandı.

Sonuç: Nefes karbonmonoksit konsantrasyonları hastanın sigara içme durumunu değerlendirmekte kolay, invazif olmayan ve hızlı bir yoldur. Micro CO cihazı taşınabilir ve kullanılışlı bir karbonmonoksit ölçüm cihazıdır. 5 ppm’den fazla değerler o kişinin çok büyük olasılıkla sigara içicisi olduğunu göstermektedir.
Carbon Monoxide Levels in the Expired Air of Smokers
Objective: There are a variety of independent methods of estimating smoking status. The measurement of carbon monoxide in the expired air has proven to be a reliable and convenient method. The purpose of this study is to determine the optimal breath carbon monoxide concentration cut-off level to distinguish actual smokers from nonsmokers.

Method: A hand held breath analyzer (Micro CO) was used to measure expired-air carbon-monoxide concentrations. Breath carbon monoxide levels were measured in 31 smokers and 30 nonsmokers.

Results: The range of carbon monoxide concentrations obtained was 0-5 parts per million (ppm) in the non-smoking group and 5-70 ppm in the smoking group. Smokers had a mean breath carbon monoxide concentration of 27.8 + 17.0 ppm and non-smokers had a mean of 1.7 +1.0 ppm (p<0.01). Mean breath carbon monoxide concentrations increased in direct proportion to the number of cigarettes smoked (p<0.01). The optimal cut-off level of breath carbon monoxide to discriminate between actual smokers and nonsmokers was 5 ppm with 96.8 % sensitivity and 96.7 % specifity.

Conclusion: Breath carbon monoxide concentration provides an easy, noninvasive, and immediate way of assessing a patient’s smoking status. Micro CO analyzer is a portable and practical analyzer for measuring expired-air carbon monoxide. A reading > 5 ppm strongly suggests that a person is a smoker.

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