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Yıl:1991; Cilt: 28; Sayı: 1>> Özet
Nöropsikiyatri Arşivi; 1991;28(1):1-10
Duygulanım Bozukluklarında Serotonerjik Disregülasyon
O Yazıcı
I. Ü. İstanbul Tıp Fakültesi Psikiyatri Anabilim Dalı, İstanbul
Duygulanım bozukluklarında serotonin (5HT) işlevine yönelik araştırmalar sürmektedir. Başlangıçta post mortem incelemeler ve BOS'taki ve idrardaki metabolitlerine yönelik araştırmalar yoğunken, son dönemlerde sinaptik dönüşüm, reseptör işlevleri, nöroendokrin düzenekler, serotonin gerialımı engellenmesi araştırma odağı haline gelmiştir. Duygulanım bozukluklarında serotonin üzerine yapılan araştırmalar ve kurulan varsayımlar . etkinliğini sürdürmektedir. Bu yazıda serotonin-duygulanım bozukluğu ilişkisine odaklasan araştırmalar gözden geçirilmiştir.
Serotonergic Dysregulation in Affective Disorders
Functions of serotonin (5HT) in affective disorders are still subject to study. Although the initial report were mainly concentrated on post-mortem studies, and the studies on the metabolites in CSF and urine, lately the main focus become synaptic turnover, receptor functions, neuroendocrine apparatus and serotonin uptake inhibition. The studies and hypotheses on serotonin in affective disorders are still in fashion. In this report the studies on serotonin-affective disorders relationship are reviewed.

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