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Yıl:2004; Cilt: 5; Sayı: 1>> Özet
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Bağımlılık Dergisi; 2004;5(1):35-39
Erkekte kısa süreli marihuana (esrar) kullanımının beklenmedik etkileri: Jinekomasti ve oligoastenospermi
T Bayraktaroğlu, E Kargı, Ç Yeşilli, G Numanoğlu, A Borazan, Y Üstündağ
Zonguldak Karaelmas Üniversitesi Tıp Fak.
Bu çalışmada kısa süreli marihuana (esrar) kullanımı sonrası oligoastenospermi ve jinekomasti belirlenen bir olgunun sunulması amaçlanmıştır.

Olgu: Otuzbir yaşında erkek, yaklaşık 20 günlük sol göğüs meme başı altında kitle yakınması ile başvurdu. Kitlenin ortaya çıkmaya başlamasından önceki yaklaşık 15 gün boyunca günlük esrar kullanımı tanımlamaktaydı. Fiziki muayenede sol meme areola altında hassas olmayan, çevre dokuya fikse olmamış 50 mm’lik kitle palpe edildi. Hastanın serum östradiol düzeyi yüksek bulundu. Ayrıca; sperm sayısının azalmış ve motilitesinin kaybolmuş olduğu saptandı. Meme ultrasonografisinde; sol memede 45 x 35 x 25 mm’lik kitle vardı. Belirlenen kitlenin total eksizyonu ile yapılan patolo- jik inceleme ile hipertrofik meme dokusuna ait fibroadipoz doku içinde duktal yapılarında kistik genişlemeler dikkati çekti. Atipi veya displazi bulgusu mevcut değildi. Hastaya bu bulgularla jinekomasti tanısı konuldu ve ek tedavi planı yapılmadı. Hasta rutin poliklinik kontrollerine çağrıldı. Bu bir yıllık dönemde esrar hiç kullanmayan hastada jinekomasti bulgusu tekrarlamadı. Medikal tedavisiz bir yıllık takipte olgunun jinekomasti açısından herhangi bir yakınması yoktu ve serum estradiol seviyesi normal bulundu. Ayrıca; kontrol sperm analizinde düzelmeye başladığı saptandı. Bu olgu, bize kısa dönem esrar kullanımı ile bile jinekomasti ve oligoastenospermi gelişebileceğini düşündürmektedir.
Unpredictable Effects of Short Term Marihuana (Cannabis) Use in a Male: Gynecomastia and Oligoasthenospermia
We aimed to present a case with oligoasthenospermia and gynecomastia after short term use of marihuana (cannabis).

Case: Thirty one [year]s-old male admitted with complaint of sensation of mass in his left breast for the last 20 days. He was using cannabis for 15 days before noticing the mass. At physical examination; he had a subareolar non-tender mass in his left breast which was approximately 50 millimeters in diameter and without signs of fixation into surrounding tissue. The patient had elevated serum estradiole levels. Sperm analysis revealed decreased sperm count and loss of sperm motility. Breast sonography revealed a hypoechoic mass 45x35x25 millimeters in diameters in his left breast. Abdominal and scrotal sonographic examinations were normal. Total excision of the defined mass revealed hypertrophic mam- mary glands with cystic dilatations of several ductal structure in a fibroadipose tissue. There was no sign of atypia and or dysplasia. Gynecomastia was diagnosed and no further treatment was planned. He was called for routine follow up. During the next one [year], he did not use cannabis and gynecomastia did not reappear. His control serum estradiol levels were decreased to normal ranges. Moreover; control sperm analyses were also evaluated as nearly normal. This case suggests that even short term use of cannabis can lead to gynecomastia and oligoasthenospermia.

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