Yıl:1996; Cilt: 2; Sayı: 1>> Özet

PsychoMed; 1996;2(1):5-12

Kortikosteroidler ve Davranış

C Cimilli

Dokuz Eylül Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalı

Endojen kortikosteroid artışı ile karakterize Cushing sendromunda ve tedavi amacıyla egzojen kortikosteroid kullanımında davranışsal belirtiler gözlenmektedir. Birçok psikiyatrik bozuklukta kortikosteroid salınımını düzenleyen hipotalamus-hipofiz-böbreküstü bezi ekseninde işlev artışı görülmektedir. Bu yazıda, Cushing sendromu ve kortikosteroid tedavisine bağlı davranış değişikliklerinin hiperkortizolemik depresyonla benzerlik ve farklılıkları, kortikosteroidlerin beyindeki etkileri gözden geçirilmiş, kortikosteroidlerin depresyon fizyopatolojisindeki rolü tartışılmıştır.

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